{"id":"W2159136796","doi":"10.1002/anie.200901345","title":"Symmetry‐Based Design for the Chemoenzymatic Synthesis of Oseltamivir (Tamiflu) from Ethyl Benzoate","year":2009,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"","keywords":"Olefin fiber; Oseltamivir; Dihydroxylation; Ethyl benzoate; Chemistry; Toluene; Cycloaddition; Formal synthesis; Stereochemistry; Combinatorial chemistry; Organic chemistry; Enantioselective synthesis; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002631303,0.0001823504,0.0002194278,0.00006507112,0.0001056913,0.00005408021,0.0003971047,0.000130342,0.001055707],"category_scores_gemma":[0.0009671412,0.0001445539,0.0002298097,0.00009826504,0.00006808882,0.0001651162,0.000015767,0.0001234118,0.00001627931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001279344,"about_ca_system_score_gemma":0.00005677082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006562537,"about_ca_topic_score_gemma":0.000002509507,"domain_scores_codex":[0.9987347,0.00001142697,0.0003855034,0.0002681985,0.0004265429,0.0001736209],"domain_scores_gemma":[0.9964015,0.00270759,0.0002936345,0.0003280618,0.0002261321,0.00004306812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001822451,0.0003502433,0.00004417954,0.00005099036,0.000306392,0.000001907884,0.0001124774,0.0001622768,0.9580855,0.000511752,0.01532042,0.02487158],"study_design_scores_gemma":[0.0004400473,0.00001577406,0.0005925709,0.000155118,0.0001721294,0.000002534307,0.0001714144,0.003477402,0.9864635,0.00372383,0.004632271,0.0001534386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1852641,0.001933132,0.6845476,0.03082745,0.004412387,0.001656989,0.005507332,0.0007266516,0.08512436],"genre_scores_gemma":[0.9961964,0.00005731515,0.001643076,0.0003163051,0.0008567534,0.000192616,0.0004233894,0.0000216112,0.0002925503],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8109323,"threshold_uncertainty_score":0.9998575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02697914788536489,"score_gpt":0.2642201826902736,"score_spread":0.2372410348049087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}