{"id":"W2159167853","doi":"10.1002/emmm.201201228","title":"miR‐33 controls the expression of biliary transporters, and mediates statin‐ and diet‐induced hepatotoxicity","year":2012,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; Memorial University of Newfoundland; National Center for Research Resources; American Heart Association","keywords":"Cholestasis; In vivo; Simvastatin; Multidrug resistance-associated protein 2; Hepatocyte; Transporter; Biology; Secretion; Cholesterol; Gene silencing; Statin; Endocrinology; Internal medicine; Chemistry; Pharmacology; ATP-binding cassette transporter; Medicine; Biochemistry; In vitro; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521933,0.0002947932,0.0002072129,0.0002158339,0.0001906099,0.0002644501,0.0001119666,0.0001792451,0.001046572],"category_scores_gemma":[0.0002007284,0.0002171014,0.0001919063,0.0001281111,0.0003137295,0.0001407267,0.0002617131,0.0003293115,0.0005296142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003274716,"about_ca_system_score_gemma":0.0002975866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007170266,"about_ca_topic_score_gemma":0.001047401,"domain_scores_codex":[0.9998595,0.00003347672,0.00001238283,0.00002072208,0.00003775933,0.0000362087],"domain_scores_gemma":[0.9998893,0.00001227856,0.00004674343,0.00001392355,0.00001295219,0.00002486873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001970999,0.00001069644,0.0004285433,0.00001965824,0.000003212516,0.000102455,0.00001088895,0.00007757773,0.9978037,0.0001647659,0.00004819585,0.001133149],"study_design_scores_gemma":[0.00002479676,0.0001994831,0.008539888,0.000005555889,0.00002514966,0.0004689345,0.00004210186,0.001430361,0.9854864,0.0001838195,0.003585381,0.000008166333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922098,0.001670804,0.003693142,0.0001823248,0.00002517518,0.00001878592,0.0002319062,0.0001573365,0.001810753],"genre_scores_gemma":[0.9971124,0.0006362749,0.0007463173,0.00003118348,0.000004070684,0.00001280217,0.0001625235,0.00001753875,0.001276816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046572,"threshold_uncertainty_score":0.003501117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01240213126993571,"score_gpt":0.2524142467864231,"score_spread":0.2400121155164874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}