{"id":"W2159234812","doi":"10.1158/0008-5472.can-09-0727","title":"Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for <i>BRAF, PIK3CA</i> , and <i>AKT1</i>","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":527,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Neuroblastoma RAS viral oncogene homolog; KRAS; HRAS; Medicine; Cancer research; AKT1; Thyroid cancer; Oncology; Thyroid; Internal medicine; Cancer; Biology; PI3K/AKT/mTOR pathway; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001188137,0.0001139015,0.000175295,0.0004048148,0.0001214844,0.0002433584,0.0001002177,0.0001437421,0.0006794028],"category_scores_gemma":[0.0003878546,0.0001162581,0.0001338255,0.0002464188,0.000189354,0.00007016984,0.0001073357,0.0001327459,0.0002080425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002508548,"about_ca_system_score_gemma":0.0001103418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002129718,"about_ca_topic_score_gemma":0.002519702,"domain_scores_codex":[0.999885,0.00001541128,0.00001026719,0.00003220978,0.00003379737,0.00002335414],"domain_scores_gemma":[0.999838,0.00004253198,0.00004009419,0.00001565963,0.00002276002,0.00004101604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006063996,0.00004918596,0.8188196,0.0000236156,0.0000376835,0.0006534623,0.0002017303,0.0001492871,0.1735219,0.00004227215,0.0001186738,0.005776178],"study_design_scores_gemma":[0.00001052508,0.0002440162,0.9883764,0.000002426306,0.00002886589,0.002722306,0.0001160175,0.0003464216,0.00783476,0.00002179585,0.0002927298,0.000003672091],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997311,0.00006822529,0.00003414944,0.000003838026,3.373997e-7,0.000001511152,0.00004215494,0.000002722746,0.0001159662],"genre_scores_gemma":[0.9996754,0.00004067037,0.00006511701,0.00000601927,0.000001434765,0.00000218581,0.0001375357,0.000001185007,0.00007040828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002129718,"threshold_uncertainty_score":0.004234672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03558343462431957,"score_gpt":0.3670218043882438,"score_spread":0.3314383697639243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}