{"id":"W2159234812","doi":"10.1158/0008-5472.can-09-0727","title":"Mutational Profile of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for <i>BRAF, PIK3CA</i> , and <i>AKT1</i>","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":527,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Neuroblastoma RAS viral oncogene homolog; KRAS; HRAS; Medicine; Cancer research; AKT1; Thyroid cancer; Oncology; Thyroid; Internal medicine; Cancer; Biology; PI3K/AKT/mTOR pathway; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000394139,0.0002137706,0.0005228783,0.0001628219,0.000161514,0.00002568298,0.00008736427,0.00005468705,0.00006908523],"category_scores_gemma":[0.00009214669,0.000176568,0.00007843752,0.0002547568,0.0003192354,0.0001215115,0.00003147521,0.0002115633,0.000001452671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000510701,"about_ca_system_score_gemma":0.0007250341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001246627,"about_ca_topic_score_gemma":0.00006417926,"domain_scores_codex":[0.998037,0.000112113,0.0003312493,0.0005244416,0.0005449367,0.0004502684],"domain_scores_gemma":[0.9985861,0.0004688999,0.0001181125,0.0002486315,0.0003200402,0.000258243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.007593359,0.00087193,0.007359152,0.001582522,0.0006166134,0.00009680989,0.001986858,0.0001467185,0.4394411,0.0005486216,0.008083164,0.5316731],"study_design_scores_gemma":[0.04199941,0.01955381,0.6594579,0.002852404,0.001388777,0.0002046111,0.002352269,0.0003353507,0.2418479,0.006035628,0.02264514,0.001326779],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9346529,0.0599454,0.00003944438,0.001425403,0.00004455418,0.002142258,0.0008670092,0.00002085933,0.0008622132],"genre_scores_gemma":[0.9873295,0.00851979,0.001740209,0.0003388585,0.0001286947,0.0014116,0.0001289795,0.00003200074,0.0003703971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6520987,"threshold_uncertainty_score":0.7200235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03558343462431957,"score_gpt":0.3670218043882438,"score_spread":0.3314383697639243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}