{"id":"W2159300982","doi":"10.1001/archneur.63.9.1250","title":"Clinical Features of Parkinson Disease Patients With Homozygous Leucine-Rich Repeat Kinase 2 G2019S Mutations","year":2006,"lang":"en","type":"article","venue":"Archives of Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke","keywords":"LRRK2; Heterozygote advantage; Mutation; Compound heterozygosity; Genetics; Disease; Phenotype; Gene; Medicine; Leucine-rich repeat; Gene mutation; Parkinson's disease; Internal medicine; Biology; Genotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004041009,0.0001845031,0.000438129,0.0001760005,0.00005139133,0.000003164621,0.0001044061,0.00005388702,0.00002088882],"category_scores_gemma":[0.00009372423,0.000138955,0.0001678976,0.0001154508,0.0003172492,0.00003709274,0.000051994,0.000160968,0.000004568429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003841732,"about_ca_system_score_gemma":0.00009065058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008411979,"about_ca_topic_score_gemma":0.0000296159,"domain_scores_codex":[0.9985541,0.0001557331,0.000412487,0.0004196475,0.0002142045,0.0002438283],"domain_scores_gemma":[0.9987298,0.000299445,0.0002451832,0.0004554016,0.00006283698,0.0002073477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004932116,0.00284878,0.9834095,0.00007192027,0.0001247811,0.0006029199,0.00004016189,0.00004956328,0.0001848345,0.0004578625,0.0002268067,0.007050726],"study_design_scores_gemma":[0.004879484,0.002717713,0.987506,0.0000335397,0.0004003423,0.00002125827,0.000003407086,0.00005186614,0.0002277734,0.001836671,0.00222621,0.00009570469],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967567,0.0003046113,0.00009168537,0.0004380255,0.00009923233,0.0004276957,0.0001697466,0.00003287281,0.001679464],"genre_scores_gemma":[0.9978492,0.00005397365,0.001180731,0.0003036218,0.00006398132,0.00002671295,0.0003065103,0.00002771016,0.0001876138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006955022,"threshold_uncertainty_score":0.566642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0096958369073349,"score_gpt":0.264027169269971,"score_spread":0.2543313323626361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}