{"id":"W2159334966","doi":"10.1038/sj.bjc.6601856","title":"Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer","year":2004,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":377,"is_retracted":false,"has_abstract":true,"ca_institutions":"Supratek Pharma (Canada)","funders":"","keywords":"Pharmacokinetics; Doxorubicin; Pharmacology; Toxicity; Medicine; Maximum tolerated dose; Poloxamer; Chemotherapy; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001245025,0.0001118555,0.0003710694,0.0001248919,0.00003515984,0.0000188143,0.00004989323,0.00004577866,0.00005143342],"category_scores_gemma":[0.00001293236,0.0001104085,0.00004673165,0.0002327574,0.00005601703,0.0002250156,0.000008903289,0.0002489664,1.103023e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002660011,"about_ca_system_score_gemma":0.00024422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00110543,"about_ca_topic_score_gemma":0.001549632,"domain_scores_codex":[0.9988126,0.00003408948,0.0004212297,0.0001443904,0.0004327511,0.0001550062],"domain_scores_gemma":[0.9992579,0.00001397638,0.0003227835,0.00006898465,0.0002352948,0.0001010442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.004699405,0.003957846,0.07952529,0.0001239386,0.0003579878,0.0001467093,0.001670046,0.001909872,0.1526463,0.000002598063,0.0000186186,0.7549413],"study_design_scores_gemma":[0.1197596,0.004662715,0.7007431,0.002138196,0.00034749,0.0001399269,0.0003720655,0.00001734066,0.1714914,0.00002682232,0.0001209291,0.0001804293],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909348,0.008193352,0.0000253692,0.0001445046,0.0001204584,0.0005267118,0.00001439243,0.000004951202,0.00003543474],"genre_scores_gemma":[0.9976441,0.001958292,0.0000421627,0.000166303,0.000128514,0.00001632126,0.000003202802,0.00002093434,0.00002020606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7547609,"threshold_uncertainty_score":0.4502329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008120481377496757,"score_gpt":0.304287108893021,"score_spread":0.2961666275155243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}