{"id":"W2159352639","doi":"10.1002/em.21932","title":"Sublinear response in <i>lacZ</i> mutant frequency of Muta<sup>™</sup>Mouse spermatogonial stem cells after low dose subchronic exposure to N‐ethyl‐N‐nitrosourea","year":2015,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Dose–response relationship; Toxicology; Mutation frequency; Pharmacology; Mutant; Andrology; Biology; Chemistry; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000391489,0.0003750661,0.0003556875,0.00013213,0.00004771528,0.00003452346,0.0002189557,0.0002391586,0.00004514258],"category_scores_gemma":[0.00001032837,0.0003805773,0.0001747261,0.0001013964,0.0001547211,0.00001322864,0.0003371575,0.0001256264,0.00003582022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001276332,"about_ca_system_score_gemma":0.0001152086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007402967,"about_ca_topic_score_gemma":0.0000367645,"domain_scores_codex":[0.9977768,0.0002701177,0.0004559406,0.0006616403,0.000373022,0.0004624919],"domain_scores_gemma":[0.9989224,0.00001267005,0.00009418836,0.0005784319,0.00001919869,0.0003731014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001597406,0.0003066348,0.006459886,0.00003194556,0.0000582719,0.0002711154,0.0006741927,0.002533105,0.9876309,0.000001964781,0.00004000977,0.0003945897],"study_design_scores_gemma":[0.001909777,0.001153497,0.006893104,0.00001830545,0.00004402652,0.00004775285,0.0006662938,0.00008783097,0.9875438,0.000004982717,0.001179123,0.0004515527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996883,0.001737559,0.0003233645,0.0001104984,0.00005882785,0.0005355886,0.0003180386,0.00001010486,0.00002307063],"genre_scores_gemma":[0.9981666,0.0001433424,0.0006484372,0.0005460187,0.00006876636,0.00008375524,0.0000872844,0.00006314498,0.0001926677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002445274,"threshold_uncertainty_score":0.9998646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00558081714997694,"score_gpt":0.2027484441795559,"score_spread":0.1971676270295789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}