{"id":"W2159413018","doi":"10.1093/hmg/ddt191","title":"Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agricultural Research Institute of Ontario; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; FightSMA; Spinal Muscular Atrophy Foundation","keywords":"SMN1; Spinal muscular atrophy; SMA*; Biology; Celecoxib; Motor neuron; Cancer research; Spinal cord; Pharmacology; Neuroscience; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00013173,0.0002633156,0.0003204157,0.0002319695,0.00009854379,0.00005607136,0.0001402355,0.0001499868,0.00008723425],"category_scores_gemma":[0.00004715515,0.0002662175,0.0001210743,0.0001975631,0.000126717,0.0000530059,0.0001481909,0.0002936104,0.0000258483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005281287,"about_ca_system_score_gemma":0.0001242126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003479617,"about_ca_topic_score_gemma":0.00004242973,"domain_scores_codex":[0.9980648,0.0001390446,0.0003067274,0.0004889558,0.0005421308,0.0004583247],"domain_scores_gemma":[0.9989915,0.00001291541,0.00005937295,0.0005037172,0.0001632637,0.0002692189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000631686,0.0003570401,0.004700608,0.0001500987,0.00006489724,0.00009415483,0.00009077978,0.001098018,0.9847256,0.0002170639,0.00004915509,0.008389416],"study_design_scores_gemma":[0.01647125,0.003913607,0.4241368,0.0003262688,0.0003158678,0.0003023126,0.0005268598,0.09659272,0.4450235,0.009276702,0.001029624,0.002084516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886736,0.0009938746,0.008564427,0.0001242265,0.00001261366,0.001008013,0.000003827955,0.0000359858,0.0005834668],"genre_scores_gemma":[0.9964564,0.0002252793,0.002438449,0.0003647944,0.00003712847,0.0001037231,0.00004614703,0.00007305512,0.000254969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5397021,"threshold_uncertainty_score":0.999979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01985470556692202,"score_gpt":0.2746610399297303,"score_spread":0.2548063343628083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}