{"id":"W2159415787","doi":"","title":"Genetically modified dendritic cells prime autoreactive T cells through a pathway independent of CD40L and interleukin 12: implications for cancer vaccines.","year":2000,"lang":"en","type":"article","venue":"PubMed","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Cytotoxic T cell; CD40; Immunology; Biology; Interleukin 12; CD8; CTL*; IL-2 receptor; Interleukin 21; Immune system; Cancer research; T cell; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001875795,0.0002047094,0.0003540548,0.00007309036,0.0001286278,0.00001856518,0.0002349755,0.0002310759,0.0002672411],"category_scores_gemma":[0.0000262684,0.0001824258,0.0001166651,0.00008396509,0.0001762456,0.0001088263,0.00004220368,0.0001709826,0.00001424124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006622849,"about_ca_system_score_gemma":0.0001029044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002597212,"about_ca_topic_score_gemma":0.00003951712,"domain_scores_codex":[0.9986222,0.0001448235,0.0004023842,0.0003349159,0.00002963592,0.0004660202],"domain_scores_gemma":[0.9991329,0.000298808,0.0001283186,0.000325915,0.00008756002,0.0000265204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00124036,0.0002306685,0.00013924,0.00002608233,0.0003289647,4.448428e-7,0.0009003367,0.00001074824,0.7356555,0.0004010547,0.0002387201,0.2608279],"study_design_scores_gemma":[0.002260242,0.0001233862,0.1128283,0.00001847276,0.00007688074,0.00001906403,0.00006593038,0.000004144572,0.8549941,0.0004916657,0.02890096,0.0002169033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857116,0.009248768,0.0007837893,0.0004195551,0.000433509,0.001924318,0.0003228959,0.0000542748,0.001101238],"genre_scores_gemma":[0.989883,0.001330981,0.0001331976,0.0002055676,0.00002457778,0.002574387,0.00002941116,0.00002900214,0.005789891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.260611,"threshold_uncertainty_score":0.743911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0199782708665502,"score_gpt":0.2423251050910549,"score_spread":0.2223468342245047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}