{"id":"W2159457776","doi":"10.1016/j.celrep.2014.07.055","title":"Intrinsically Disordered Segments Affect Protein Half-Life in the Cell and during Evolution","year":2014,"lang":"en","type":"article","venue":"Cell Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":258,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Magyar Tudományos Akadémia; Medical Research Council; FP7 People: Marie-Curie Actions; National Cancer Institute; National Institutes of Health; Virgo Consortium; Welch Foundation","keywords":"Proteasome; Protein turnover; Cell biology; Biology; Phenotype; Regulator; Protein degradation; Gene; Saccharomyces cerevisiae; Genetics; Protein biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003224442,0.0001839392,0.0001875932,0.000418936,0.0003014774,0.00042509,0.0002868902,0.0004737638,0.0007576932],"category_scores_gemma":[0.000446415,0.0001294788,0.000198391,0.0003311946,0.0004800814,0.000420735,0.0004591418,0.0005053101,0.000211466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004212034,"about_ca_system_score_gemma":0.0001388397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003902988,"about_ca_topic_score_gemma":0.0004890533,"domain_scores_codex":[0.9997995,0.00004727215,0.0000194942,0.00005785236,0.00004307709,0.00003279253],"domain_scores_gemma":[0.9995592,0.0001211366,0.0001349345,0.0000454744,0.00004589102,0.00009340837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003475223,0.00001620587,0.0110786,0.00002902806,0.00002905639,0.000348793,0.0001474134,0.0002922772,0.9808602,0.0008826209,0.00005518974,0.005913121],"study_design_scores_gemma":[0.00004883175,0.0006912538,0.5213414,0.00005044472,0.0002249478,0.0072135,0.0004929401,0.004361236,0.4387548,0.003835174,0.02285945,0.0001258853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962643,0.001488726,0.001087444,0.00006427961,0.00001095019,0.000001908032,0.0001549829,0.00001746884,0.0009099989],"genre_scores_gemma":[0.9980147,0.0004742427,0.0006451146,0.00004414342,0.000007915393,0.000003506862,0.0002144436,0.0000193896,0.0005764176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007576932,"threshold_uncertainty_score":0.00305599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005729576911951188,"score_gpt":0.2068638059832234,"score_spread":0.2011342290712722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}