{"id":"W2159463313","doi":"10.1016/j.healun.2004.11.057","title":"Sirolimus induces endothelial progenitor cell apoptosis","year":2005,"lang":"en","type":"article","venue":"The Journal of Heart and Lung Transplantation","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Sirolimus; Calcineurin; Progenitor cell; Endothelial progenitor cell; PI3K/AKT/mTOR pathway; Cancer research; Apoptosis; Endothelial stem cell; Progenitor; Discovery and development of mTOR inhibitors; Tacrolimus; Homeostasis; Stem cell; Biology; Medicine; Cell biology; Internal medicine; Transplantation; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002201088,0.0003525892,0.0003995087,0.0003475164,0.0001750886,0.0003936045,0.0001886578,0.0003186523,0.001781796],"category_scores_gemma":[0.0001436679,0.0002000119,0.000364059,0.0002398387,0.0001518373,0.0002041516,0.0001653067,0.001123728,0.0004506297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002780145,"about_ca_system_score_gemma":0.0003716959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005575856,"about_ca_topic_score_gemma":0.0009114905,"domain_scores_codex":[0.9997955,0.00004943741,0.00002402448,0.00001952579,0.00005493735,0.0000565102],"domain_scores_gemma":[0.9998879,0.00003150971,0.00002248112,0.00002201356,0.00001283336,0.00002310326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001695292,0.0003500543,0.0005107922,0.0001356715,0.00005039833,0.0002470929,0.00004737801,0.0002984501,0.9827865,0.0008246662,0.0008266619,0.01222707],"study_design_scores_gemma":[0.0003418161,0.001861423,0.006814142,0.00001242529,0.0000668041,0.0006574382,0.00005697733,0.002047521,0.9809564,0.0002409819,0.006934948,0.000009238879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899381,0.003033523,0.001841238,0.0002896121,0.0001145172,0.00004552027,0.0004180972,0.0001971462,0.004122325],"genre_scores_gemma":[0.9936068,0.001616038,0.0008142591,0.000136057,0.00003271059,0.00005687907,0.0006422583,0.00001424822,0.003080694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001781796,"threshold_uncertainty_score":0.005960703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008178106068666553,"score_gpt":0.2489761875461063,"score_spread":0.2407980814774397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}