{"id":"W2159470314","doi":"10.1111/fcp.12157","title":"The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats","year":2015,"lang":"en","type":"article","venue":"Fundamental and Clinical Pharmacology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Health and Medical Research Council; National Institutes of Health","keywords":"Isoniazid; Pharmacokinetics; Steatosis; Alanine transaminase; Pharmacology; Medicine; Toxicity; Internal medicine; Transaminase; Liver injury; Endocrinology; Chemistry; Tuberculosis; Enzyme; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003807079,0.0003150331,0.0005589654,0.0000997449,0.0002973059,0.00002661147,0.0002293466,0.000475051,0.0001415033],"category_scores_gemma":[0.0002642869,0.0002318983,0.000119008,0.0002155728,0.0009052421,0.0001103054,0.0002388179,0.001748685,0.00004373969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007929325,"about_ca_system_score_gemma":0.00005644828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007168906,"about_ca_topic_score_gemma":0.00006783823,"domain_scores_codex":[0.9953556,0.00264349,0.0008063928,0.0004818687,0.0001945414,0.0005181079],"domain_scores_gemma":[0.9959847,0.003129398,0.0002689565,0.0001332912,0.00004622717,0.0004374424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01482994,0.001412522,0.6731694,0.0002047108,0.0007526599,0.0002385282,0.0008342813,0.0002219685,0.08784077,0.0003178577,0.01222828,0.2079491],"study_design_scores_gemma":[0.03793527,0.01414667,0.08595457,0.0001087081,0.001006869,0.0001205784,0.0004580915,0.02141553,0.4968595,0.001521857,0.3393006,0.001171801],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903561,0.0009746658,0.000005722644,0.001653776,0.003706638,0.001013575,0.00003053841,0.00004512149,0.002213799],"genre_scores_gemma":[0.994787,0.001658567,0.00002004718,0.002690648,0.0004995689,0.0001000978,0.00000589908,0.00002294647,0.0002152048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5872148,"threshold_uncertainty_score":0.9456538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1581484431520603,"score_gpt":0.4887832471259452,"score_spread":0.3306348039738848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}