{"id":"W2159470314","doi":"10.1111/fcp.12157","title":"The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats","year":2015,"lang":"en","type":"article","venue":"Fundamental and Clinical Pharmacology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Health and Medical Research Council; National Institutes of Health","keywords":"Isoniazid; Pharmacokinetics; Steatosis; Alanine transaminase; Pharmacology; Medicine; Toxicity; Internal medicine; Transaminase; Liver injury; Endocrinology; Chemistry; Tuberculosis; Enzyme; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002161014,0.0004994639,0.000369485,0.000535671,0.0001606146,0.0001759912,0.0001897301,0.0003243817,0.001263429],"category_scores_gemma":[0.0001507184,0.0002435308,0.0004055284,0.0001600616,0.0003707254,0.0004024507,0.0002006237,0.000712666,0.0003427939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002724932,"about_ca_system_score_gemma":0.0001764298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009235656,"about_ca_topic_score_gemma":0.00146963,"domain_scores_codex":[0.9998534,0.00001944024,0.00001291024,0.00003695906,0.00002741916,0.0000499047],"domain_scores_gemma":[0.9997097,0.00002153886,0.0001041322,0.00003052619,0.0000364547,0.00009758381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007003969,0.0007019204,0.00233809,0.00005488888,0.00001948086,0.0001673827,0.00008212129,0.00006320897,0.9856145,0.00005398939,0.00008603061,0.003814423],"study_design_scores_gemma":[0.0003180653,0.03426513,0.1390138,0.00002638111,0.0001705896,0.000591639,0.0003843801,0.0009756962,0.8208782,0.0002212261,0.003094262,0.0000606067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980004,0.0007459401,0.0004261183,0.00005778908,0.00003003621,0.00002087812,0.0002587631,0.00003165234,0.0004283686],"genre_scores_gemma":[0.9927936,0.001256459,0.0009855678,0.0001124206,0.00003785633,0.00008988458,0.0004559643,0.00002481309,0.00424357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001263429,"threshold_uncertainty_score":0.004226625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1581484431520603,"score_gpt":0.4887832471259452,"score_spread":0.3306348039738848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}