{"id":"W2159474576","doi":"10.1124/dmd.112.046631","title":"Chronic Doxorubicin Cardiotoxicity Modulates Cardiac Cytochrome P450-Mediated Arachidonic Acid Metabolism in Rats","year":2012,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Cardiotoxicity; Pharmacology; Chemistry; Cytochrome P450; Arachidonic acid; Doxorubicin; CYP2E1; Enzyme; Toxicity; Biochemistry; Internal medicine; Medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004713679,0.0003095404,0.0005311407,0.000142307,0.0001395238,0.00003352709,0.0001307249,0.0002342639,0.00003257005],"category_scores_gemma":[0.00003223794,0.000277875,0.0001717794,0.0001886617,0.0001162962,0.00004615564,0.0001404453,0.0002171557,0.00002479954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002596928,"about_ca_system_score_gemma":0.00006109013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009664392,"about_ca_topic_score_gemma":0.00002712906,"domain_scores_codex":[0.9981177,0.000315991,0.0003323326,0.0004583553,0.0001757931,0.0005998221],"domain_scores_gemma":[0.9992519,0.00002180518,0.0001013164,0.0003108986,0.000065058,0.0002490185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000891431,0.0001020322,0.001551108,0.00002533247,0.00009098365,0.000003970952,0.0001419032,0.00002839556,0.9952798,0.0004262002,0.0006095838,0.001651485],"study_design_scores_gemma":[0.00135048,0.00003969659,0.3024872,0.00001356557,0.0002132133,0.00002051961,0.00006341057,0.0001337066,0.6755765,0.00007338655,0.01962381,0.0004045019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9168949,0.08151379,0.00008792699,0.0002070869,0.000529608,0.0003718769,0.0001398623,0.00002599976,0.0002289974],"genre_scores_gemma":[0.9927207,0.004120971,0.0001158619,0.000576457,0.001549207,0.00009193541,0.0007022172,0.00003548335,0.00008722714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3197034,"threshold_uncertainty_score":0.9999673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00599184311036717,"score_gpt":0.2371367171386814,"score_spread":0.2311448740283142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}