{"id":"W2159489772","doi":"10.1158/1078-0432.ccr-06-1817","title":"An Optimized Clinical Regimen for the Oncolytic Virus PV701","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre","funders":"","keywords":"Tolerability; Medicine; Dosing; Regimen; Oncolytic virus; Bolus (digestion); Pharmacokinetics; Clinical trial; Toxicity; Adverse effect; Pharmacology; Internal medicine; Anesthesia; Urology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002894621,0.0004639755,0.0006382871,0.0004088857,0.0001598479,0.0004518922,0.0004571658,0.0004082001,0.003380549],"category_scores_gemma":[0.0004961073,0.0001429551,0.0002680432,0.0004754664,0.0002737449,0.0003789436,0.000318349,0.001466366,0.001159566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004348989,"about_ca_system_score_gemma":0.0005357576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002639118,"about_ca_topic_score_gemma":0.0003807362,"domain_scores_codex":[0.9997734,0.00006200923,0.00001688276,0.00004542783,0.00005447619,0.00004774983],"domain_scores_gemma":[0.9998715,0.00002047778,0.0000386333,0.00002090213,0.00001742186,0.00003108845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03227521,0.01148658,0.004536994,0.0007360104,0.0001919649,0.0002716822,0.0002479415,0.01684969,0.4931676,0.001542916,0.008373464,0.4303199],"study_design_scores_gemma":[0.03799779,0.3269405,0.05298473,0.000269789,0.0008176549,0.005559809,0.0001630593,0.02811827,0.4063414,0.002662134,0.1379036,0.0002411994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668256,0.004882135,0.0168457,0.0004002747,0.0002639044,0.002237153,0.000891325,0.0005772113,0.007076742],"genre_scores_gemma":[0.9704354,0.001600703,0.02115538,0.0003447726,0.0001240652,0.001860647,0.001690382,0.00009661358,0.002691936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003380549,"threshold_uncertainty_score":0.01130903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2683399938072698,"score_gpt":0.5974442074075578,"score_spread":0.329104213600288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}