{"id":"W2159504684","doi":"10.1038/gene.2014.6","title":"MHC associations with clinical and autoantibody manifestations in European SLE","year":2014,"lang":"en","type":"review","venue":"Genes and Immunity","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université de Montréal","funders":"National Center for Research Resources; National Institute of Dental and Craniofacial Research; Instituto de Salud Carlos III; University of California, San Francisco; National Institutes of Health; National Institute of Mental Health; Vetenskapsrådet; European Science Foundation; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Wellcome Trust; Lupus Research Alliance; Rheumatology Research Foundation; U.S. Department of Defense; European Commission; University of Pittsburgh; National Institute of General Medical Sciences; Massachusetts General Hospital; U.S. Department of Veterans Affairs; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Versus Arthritis","keywords":"Autoantibody; Immunology; Major histocompatibility complex; Biology; Human leukocyte antigen; Allele; Phenotype; Single-nucleotide polymorphism; Antibody; Autoimmunity; Genotype; Genetics; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001033321,0.0006113913,0.002053879,0.002913677,0.0001345094,0.000697937,0.0006579951,0.000815833,0.001837208],"category_scores_gemma":[0.001475439,0.0002362851,0.00106042,0.003757503,0.0002884436,0.0005610459,0.0004795164,0.0005356707,0.0002417635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004031355,"about_ca_system_score_gemma":0.0009535489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00130145,"about_ca_topic_score_gemma":0.002054618,"domain_scores_codex":[0.9996543,0.00009533982,0.00008457215,0.00007282598,0.00007483865,0.00001812222],"domain_scores_gemma":[0.9992808,0.0004090554,0.0001756045,0.00001539223,0.00008434534,0.0000349143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004704556,0.00007258702,0.006152505,0.07852836,0.003173234,0.0005206459,0.00009910481,0.0004454168,0.0007832277,0.001051603,0.009615801,0.899087],"study_design_scores_gemma":[0.0004990424,0.0009759382,0.1225467,0.1091654,0.03248241,0.01470866,0.0004846032,0.0006854201,0.001600447,0.005515086,0.7111623,0.0001739922],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002354801,0.9995506,0.00002217133,0.00006471566,0.00002192011,0.000001253788,0.00001106568,9.339794e-7,0.0000917498],"genre_scores_gemma":[0.002806786,0.9968717,0.00007671767,0.00007927586,0.00006566674,0.000003842495,0.00003009988,5.144777e-7,0.00006554373],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002913677,"threshold_uncertainty_score":0.006146014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1083849457589381,"score_gpt":0.4275679713800424,"score_spread":0.3191830256211042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}