{"id":"W2159539926","doi":"10.1186/1750-1326-4-2","title":"Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification","year":2009,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias; National Health and Medical Research Council; York University; International Copper Association; National Institutes of Health; National Center for Research Resources; Comisión Nacional de Investigación Científica y Tecnológica; Alzheimer's Association","keywords":"Intracellular; Caenorhabditis elegans; Amyloid (mycology); Cell biology; Inclusion body myositis; P3 peptide; Transgene; Peptide; Chemistry; Neurodegeneration; Genetically modified mouse; Biology; Biochemistry; Amyloid precursor protein; Alzheimer's disease; Internal medicine; Medicine; Myositis; Disease; Gene; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005980301,0.0003444164,0.0001706453,0.0001963213,0.0002103495,0.0001549581,0.0001989019,0.0002584143,0.0006936996],"category_scores_gemma":[0.00006896185,0.0001108957,0.0001786622,0.00008920759,0.0002134927,0.000126051,0.0001661622,0.0002982719,0.0001865474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003219048,"about_ca_system_score_gemma":0.0001858127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001874865,"about_ca_topic_score_gemma":0.002604799,"domain_scores_codex":[0.9999238,0.000004800072,0.000009899923,0.000024527,0.00002164034,0.0000152618],"domain_scores_gemma":[0.9998665,0.00001704697,0.00005141293,0.00001236409,0.00002034939,0.00003237857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003183062,0.00001029189,0.00021404,0.00001727659,0.000001696004,0.00005457361,0.000008501051,0.00001966639,0.9994565,0.00001359948,0.000008027598,0.0001640499],"study_design_scores_gemma":[0.00001691517,0.0002644792,0.02448208,0.00001335619,0.00002596945,0.0004138153,0.00007124501,0.001239425,0.9724898,0.00005374026,0.0009198785,0.000009145575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982716,0.0003449169,0.0006016254,0.0000312856,0.0000100854,0.00001109195,0.0002560422,0.00002771285,0.0004456257],"genre_scores_gemma":[0.9961848,0.0002956556,0.001628815,0.00002130505,0.00000397229,0.00003010563,0.0002845752,0.0000155799,0.001535244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001874865,"threshold_uncertainty_score":0.003727913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758772224209651,"score_gpt":0.2668971845913455,"score_spread":0.249309462349249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}