{"id":"W2159587574","doi":"10.1056/nejmoa0807865","title":"An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist","year":2009,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":992,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Memorial University of Newfoundland","funders":"National Institutes of Health","keywords":"Medicine; Interleukin 1 receptor antagonist; Anakinra; Receptor antagonist; Antagonist; Disease; Immunology; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577624,0.001114818,0.0003843071,0.0004448958,0.0008658969,0.0002444022,0.0002699667,0.0003250337,0.002486067],"category_scores_gemma":[0.0005385089,0.0001559868,0.0002054253,0.0004165132,0.0005531642,0.0002155986,0.0003306545,0.0004305579,0.0004151727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006547743,"about_ca_system_score_gemma":0.0007161942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005384433,"about_ca_topic_score_gemma":0.006402462,"domain_scores_codex":[0.9998329,0.00001813005,0.00001633609,0.00005210624,0.0000326658,0.00004793056],"domain_scores_gemma":[0.9996884,0.00006362287,0.0001164542,0.00001729171,0.00004175277,0.00007252848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.0006605264,0.0003039836,0.3374757,0.0003540628,0.0001592877,0.5123278,0.00213273,0.0004655768,0.1103467,0.001936364,0.002546483,0.03129074],"study_design_scores_gemma":[0.00008930288,0.0003384867,0.2110199,0.00006355295,0.0001312377,0.774341,0.0002426433,0.0004262337,0.007707647,0.0001737946,0.005447164,0.00001890509],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946744,0.0009108288,0.0006748495,0.0001396035,0.0000193487,0.00002894308,0.0001843307,0.00005492694,0.003312709],"genre_scores_gemma":[0.9980085,0.0002854053,0.0006285308,0.0001044477,0.00002749944,0.000009473762,0.0001119333,0.00001386662,0.0008103153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005384433,"threshold_uncertainty_score":0.01070619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004121501510238166,"score_gpt":0.226170194514612,"score_spread":0.2220486930043738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}