{"id":"W2159594748","doi":"10.1210/en.2009-1294","title":"Genistein Induces Pancreatic β-Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice","year":2010,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of Illinois at Urbana-Champaign; National Institutes of Health; Qingdao University; Virginia Polytechnic Institute and State University; City of Hope; University of Pittsburgh; National Center for Complementary and Integrative Health; Joslin Diabetes Center; University of Minnesota; Northwestern University; University of Miami; University of Pennsylvania; Massachusetts General Hospital; Commonwealth Health Research Board; American Diabetes Association","keywords":"Genistein; Cell growth; Endocrinology; Internal medicine; Signal transduction; Biology; Insulin; Islet; Phytoestrogens; Cell biology; Estrogen; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000213643,0.0008601189,0.0003702754,0.00104741,0.0001970846,0.0003530227,0.0003314543,0.0004500206,0.001418535],"category_scores_gemma":[0.00009749165,0.0004010694,0.0003986519,0.0002939325,0.000354702,0.0002842216,0.0002495281,0.001000756,0.0005156762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000460166,"about_ca_system_score_gemma":0.000315652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007165796,"about_ca_topic_score_gemma":0.001544981,"domain_scores_codex":[0.9998512,0.00002268082,0.00001455906,0.00004615262,0.00003401325,0.0000313514],"domain_scores_gemma":[0.999827,0.00001553312,0.00006809115,0.00001725625,0.000008877506,0.00006338447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000542412,0.0001102986,0.0002712442,0.00004419418,0.0000164173,0.00005492082,0.0000139082,0.00005447394,0.9966174,0.00009992448,0.00006862288,0.002106131],"study_design_scores_gemma":[0.0002489762,0.001524867,0.01030028,0.00003523436,0.00008497415,0.0003917571,0.00003808094,0.0007536593,0.9804431,0.0001800073,0.005988682,0.00001051713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984925,0.004018694,0.004692448,0.0002907715,0.00006515433,0.0001264085,0.001330484,0.0006655119,0.00388553],"genre_scores_gemma":[0.9755322,0.005230288,0.00701924,0.0002716336,0.00004848948,0.0002186857,0.002006173,0.0001861645,0.009487142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001418535,"threshold_uncertainty_score":0.004745483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02152150416160495,"score_gpt":0.2475531130117825,"score_spread":0.2260316088501776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}