{"id":"W2159594748","doi":"10.1210/en.2009-1294","title":"Genistein Induces Pancreatic β-Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice","year":2010,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of Illinois at Urbana-Champaign; National Institutes of Health; Qingdao University; Virginia Polytechnic Institute and State University; City of Hope; University of Pittsburgh; National Center for Complementary and Integrative Health; Joslin Diabetes Center; University of Minnesota; Northwestern University; University of Miami; University of Pennsylvania; Massachusetts General Hospital; Commonwealth Health Research Board; American Diabetes Association","keywords":"Genistein; Cell growth; Endocrinology; Internal medicine; Signal transduction; Biology; Insulin; Islet; Phytoestrogens; Cell biology; Estrogen; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000102019,0.0001268845,0.0003110864,0.0001431322,0.0000438066,0.000007920318,0.00004406925,0.0001008967,0.00004081965],"category_scores_gemma":[0.0004643599,0.0001129858,0.00003226176,0.0001481007,0.00008514083,0.0001036217,0.00003242022,0.0002402119,0.000006347015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002239546,"about_ca_system_score_gemma":0.0000601386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001050293,"about_ca_topic_score_gemma":0.00001142621,"domain_scores_codex":[0.9989907,0.00006763199,0.0003317229,0.000238105,0.0001222436,0.0002496431],"domain_scores_gemma":[0.999342,0.000268224,0.0001381128,0.0001470654,0.00005929912,0.00004532235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005869857,0.0002226611,0.2271385,0.0001130832,0.00001490107,0.000002028045,0.0006396996,0.000008964932,0.7706259,0.0002525079,0.000007371883,0.0009156946],"study_design_scores_gemma":[0.002313095,0.0002978932,0.06704892,0.0000657945,0.00003947554,0.000006900661,0.0003981274,0.0008429463,0.9284518,0.0003311029,0.0001113869,0.00009256288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980801,0.0002153325,0.00005780904,0.0001351114,0.0001500405,0.0004490849,0.00000490384,0.00003414318,0.0008734959],"genre_scores_gemma":[0.9977747,0.00003609881,0.001787122,0.000164386,0.00006115068,0.00006817318,0.00003289749,0.00001244254,0.00006306738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1600895,"threshold_uncertainty_score":0.4607427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02152150416160495,"score_gpt":0.2475531130117825,"score_spread":0.2260316088501776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}