{"id":"W2159606069","doi":"10.1158/0008-5472.can-04-2312","title":"Inactivation of Anthracyclines by Cellular Peroxidase","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Doxorubicin; Chemistry; Clonogenic assay; Daunorubicin; Anthracycline; Biochemistry; Cytotoxic T cell; Cancer cell; Cardiotoxicity; Pharmacology; K562 cells; Myeloperoxidase; Leukemia; In vitro; Cancer; Biology; Internal medicine; Chemotherapy; Medicine; Toxicity; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003285513,0.00005686702,0.0001428387,0.0001044377,0.0000589372,0.000007642696,0.00005459142,0.00007430275,0.00021731],"category_scores_gemma":[0.00009762347,0.00005162916,0.00004946572,0.0002794031,0.0001154116,0.00009833465,0.00001455425,0.0002301638,0.00001287251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002023499,"about_ca_system_score_gemma":0.0001441438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001444739,"about_ca_topic_score_gemma":0.000006525313,"domain_scores_codex":[0.9990715,0.00004930564,0.0001474139,0.0001511002,0.0004012028,0.0001794341],"domain_scores_gemma":[0.9993573,0.00005352513,0.00003271592,0.0001836977,0.000295654,0.00007703827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001188872,0.00009121101,0.0003383078,0.00006746833,0.00002178295,0.000002132216,0.0002135467,0.000004787936,0.9497229,0.00005663804,0.005557162,0.0438051],"study_design_scores_gemma":[0.0007712659,0.00008761721,0.0007696564,0.00008939646,0.000007205424,0.000002107801,0.0001022333,0.00006026666,0.9746364,0.00004463427,0.02338514,0.00004409054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934604,0.0009606133,0.0002968177,0.003325892,0.00002920362,0.000275935,0.000006985733,0.00001715485,0.00162697],"genre_scores_gemma":[0.9970656,0.0005993455,0.0001226977,0.0001482497,0.0004172273,0.0000421237,0.00001655691,0.00001415407,0.001574058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04376101,"threshold_uncertainty_score":0.2379392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06947277325698539,"score_gpt":0.426184454000998,"score_spread":0.3567116807440126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}