{"id":"W2159660532","doi":"10.1016/j.jsbmb.2014.05.009","title":"Multiple roles for udp-glucuronosyltransferase (UGT)2B15 and UGT2B17 enzymes in androgen metabolism and prostate cancer evolution","year":2014,"lang":"en","type":"review","venue":"The Journal of Steroid Biochemistry and Molecular Biology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Prostate cancer; Dihydrotestosterone; Glucuronidation; Androgen; Androgen receptor; Androsterone; Endocrinology; Dehydroepiandrosterone; Testosterone (patch); Glucuronosyltransferase; Internal medicine; Intracrine; Chemistry; Cancer research; Enzyme; Biology; Cancer; Hormone; Medicine; Biochemistry; Receptor; Steroid; Microsome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005182102,0.000277783,0.001057237,0.0001073655,0.00007055187,0.00001707066,0.00009627531,0.0002513994,0.000002372126],"category_scores_gemma":[0.00006572653,0.0001532311,0.0001372407,0.00007224262,0.0003137733,0.00002564843,0.00005527218,0.0003285728,1.067437e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005256583,"about_ca_system_score_gemma":0.0002324939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001995292,"about_ca_topic_score_gemma":0.000007985715,"domain_scores_codex":[0.9988067,0.0001682819,0.0004464653,0.0002352351,0.0000843431,0.0002590471],"domain_scores_gemma":[0.9992334,0.0001412351,0.0002460572,0.0001411984,0.00009596678,0.0001421116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003426767,0.0001794726,0.001427625,0.02425939,0.001940824,0.0000933034,0.000532137,9.518672e-7,0.1460395,0.00007060373,0.0001362594,0.8218932],"study_design_scores_gemma":[0.02743232,0.003681667,0.000412223,0.02249077,0.01093985,0.005498052,0.0005941779,0.00007396865,0.2292526,0.0009044327,0.6973328,0.001387146],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.113259,0.8855039,0.00012026,0.000302396,0.00004213108,0.0006416946,0.0001227623,0.000002895765,0.000004948403],"genre_scores_gemma":[0.06545042,0.9340999,0.00008343044,0.00004774141,0.000130696,0.00005330836,0.00005913227,0.00002093733,0.00005444301],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.820506,"threshold_uncertainty_score":0.6248581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0176878938700814,"score_gpt":0.3398053258894501,"score_spread":0.3221174320193687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}