{"id":"W2159738130","doi":"10.1093/eurheartj/eht571","title":"Mendelian randomization of blood lipids for coronary heart disease","year":2014,"lang":"en","type":"review","venue":"European Heart Journal","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":792,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute; Münchner Zentrum für Gesundheitswissenschaften; World Cancer Research Fund; Medical Research Council; U.S. Public Health Service; Universität Ulm; Universitetet i Oslo; Stockholms Läns Landsting; University of Bristol; Knut och Alice Wallenbergs Stiftelse; Agentschap NL; Hjärt-Lungfonden; Academy of Finland; Karolinska Institutet; ZonMw; National Institutes of Health; Rosetrees Trust; European Commission; Research Councils UK; Bundesministerium für Bildung und Forschung; National Institute on Aging; Queen Mary University of London; National Institute for Health and Care Research; Government of the United Kingdom; Wellcome Trust; University College London; Sahlgrenska Akademin; British Heart Foundation; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Economic and Social Research Council; U.S. Department of Health and Human Services; London School of Hygiene and Tropical Medicine; European Foundation for the Study of Diabetes; AstraZeneca","keywords":"Mendelian randomization; Single-nucleotide polymorphism; Medicine; Allele; Internal medicine; Cholesterol; Genetics; Gastroenterology; Genotype; Biology; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001959153,0.0002588776,0.001005027,0.00009231296,0.0001510351,0.00002178149,0.0002196787,0.0001431709,0.00002864844],"category_scores_gemma":[0.0006323558,0.0002122679,0.0007984499,0.00006337775,0.00005379148,0.000002308698,0.00008455572,0.000199458,0.00002033577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001187813,"about_ca_system_score_gemma":0.0002438716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.916808e-7,"about_ca_topic_score_gemma":4.039959e-7,"domain_scores_codex":[0.9970263,0.00145382,0.0008265683,0.0003013659,0.0001100818,0.0002818663],"domain_scores_gemma":[0.9985877,0.0001197701,0.0005901285,0.0003253261,0.0001558487,0.0002211872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009043528,0.0007757692,0.006669176,0.01150919,0.003705732,0.00002648427,0.0000558764,0.0005547779,0.001228534,0.0001344809,0.4925697,0.4818659],"study_design_scores_gemma":[0.001298523,0.0003351106,0.000768827,0.0007025381,0.0009525397,0.0001987159,0.000002666414,0.00000979438,0.00000417732,0.00002554263,0.9954963,0.0002052973],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002381197,0.9941027,0.004082655,0.0001691512,0.0005042363,0.0005033499,0.00009519449,0.000006596746,0.0002979527],"genre_scores_gemma":[0.001222648,0.9917126,0.003253062,0.0003242347,0.002135675,0.00001957889,0.0004685475,0.00008650032,0.0007771954],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5029266,"threshold_uncertainty_score":0.8656034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04362524867332195,"score_gpt":0.3354216637858156,"score_spread":0.2917964151124936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}