{"id":"W2159738130","doi":"10.1093/eurheartj/eht571","title":"Mendelian randomization of blood lipids for coronary heart disease","year":2014,"lang":"en","type":"review","venue":"European Heart Journal","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":792,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute; Münchner Zentrum für Gesundheitswissenschaften; World Cancer Research Fund; Medical Research Council; U.S. Public Health Service; Universität Ulm; Universitetet i Oslo; Stockholms Läns Landsting; University of Bristol; Knut och Alice Wallenbergs Stiftelse; Agentschap NL; Hjärt-Lungfonden; Academy of Finland; Karolinska Institutet; ZonMw; National Institutes of Health; Rosetrees Trust; European Commission; Research Councils UK; Bundesministerium für Bildung und Forschung; National Institute on Aging; Queen Mary University of London; National Institute for Health and Care Research; Government of the United Kingdom; Wellcome Trust; University College London; Sahlgrenska Akademin; British Heart Foundation; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Economic and Social Research Council; U.S. Department of Health and Human Services; London School of Hygiene and Tropical Medicine; European Foundation for the Study of Diabetes; AstraZeneca","keywords":"Mendelian randomization; Single-nucleotide polymorphism; Medicine; Allele; Internal medicine; Cholesterol; Genetics; Gastroenterology; Genotype; Biology; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07447067,0.002141085,0.004115132,0.002119093,0.0005504222,0.00183197,0.002505314,0.002018831,0.003995719],"category_scores_gemma":[0.1599545,0.0007736547,0.00512989,0.002736254,0.002245234,0.00156471,0.001252519,0.001486583,0.0003819098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001049336,"about_ca_system_score_gemma":0.001551049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001853372,"about_ca_topic_score_gemma":0.001245691,"domain_scores_codex":[0.8517305,0.1260711,0.003477206,0.01183222,0.005936118,0.0009528575],"domain_scores_gemma":[0.9354418,0.04788607,0.006496185,0.008527331,0.001283324,0.0003652712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03746027,0.0005840777,0.3133921,0.009064503,0.1798003,0.002421655,0.001068344,0.03968513,0.005469857,0.1222484,0.0152119,0.2735933],"study_design_scores_gemma":[0.04155912,0.009539191,0.1258538,0.002788487,0.1025795,0.005358295,0.00036566,0.2667772,0.006575929,0.4064583,0.03157029,0.000574138],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.1971354,0.02250667,0.7637747,0.00275945,0.001809786,0.003723739,0.003134772,0.001818907,0.003336678],"genre_scores_gemma":[0.7942692,0.002949602,0.1939416,0.001381291,0.0003856479,0.004358524,0.001240909,0.0001704747,0.001302739],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.07447067,"threshold_uncertainty_score":0.3938432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04362524867332195,"score_gpt":0.3354216637858156,"score_spread":0.2917964151124936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}