{"id":"W2159793198","doi":"10.1021/jm4000837","title":"X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Chemistry; Kinase; MAPK7; Protein kinase domain; Binding site; Angiogenesis; Structure–activity relationship; Computational biology; Protein kinase A; Biochemistry; Cancer research; Cyclin-dependent kinase 2; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233551,0.0001502639,0.0002999252,0.00004013163,0.00001735853,0.00001076236,0.0002114093,0.0001459576,0.000428962],"category_scores_gemma":[0.00004848766,0.0001060828,0.00007417533,0.00008475683,0.0001268665,0.000008949944,0.00003761749,0.0002639777,0.000001081931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002100971,"about_ca_system_score_gemma":0.0001394428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001063194,"about_ca_topic_score_gemma":0.000004500575,"domain_scores_codex":[0.9988688,0.00002322936,0.00045163,0.0001476014,0.000323472,0.0001852569],"domain_scores_gemma":[0.9990751,0.00001332627,0.0003610023,0.0001903607,0.0002157944,0.0001443949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002186153,0.00006111254,0.003278716,0.0001027887,0.00003608549,0.0000474323,0.00006801767,0.00002257022,0.9907823,0.000002628749,0.004975397,0.0004043856],"study_design_scores_gemma":[0.002107209,0.0007165939,0.01350054,0.0001724846,0.00002103564,0.0007729189,0.0007314511,0.000008312301,0.9728249,0.00005439045,0.008935367,0.0001547713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977893,0.0006759308,0.0001601049,0.00014136,0.00007448631,0.0000737011,0.00001025399,0.00000163263,0.001073237],"genre_scores_gemma":[0.9977536,0.00005196293,0.001137701,0.00005993244,0.0008441582,0.00000116592,0.00002610706,0.00001385696,0.0001115325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01795732,"threshold_uncertainty_score":0.4696833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007936707667701498,"score_gpt":0.2080069232604576,"score_spread":0.2000702155927561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}