{"id":"W2159798757","doi":"10.1128/jvi.79.7.3969-3978.2005","title":"Inhibition of RIG-I-Dependent Signaling to the Interferon Pathway during Hepatitis C Virus Expression and Restoration of Signaling by IKKε","year":2005,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Albert-Ludwigs-Universität Freiburg; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"TRIF; Biology; Innate immune system; Interferon; IκB kinase; Signal transduction; Cell biology; Phosphorylation; Ectopic expression; Kinase; RIG-I; Replicon; NS3; Toll-like receptor; NF-κB; Virology; Immune system; Hepatitis C virus; Immunology; Biochemistry; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005993454,0.0001018476,0.0003069279,0.0002366431,0.0000567083,0.0000054551,0.0001145829,0.0001570307,0.0001262753],"category_scores_gemma":[0.000107761,0.00007341852,0.00006138544,0.00006043663,0.00009189988,0.0001370881,0.0000646413,0.00030399,0.000007031499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005025147,"about_ca_system_score_gemma":0.00002928589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000975001,"about_ca_topic_score_gemma":0.0001185402,"domain_scores_codex":[0.9985275,0.0004610222,0.0007104598,0.00009384174,0.00005224882,0.0001549384],"domain_scores_gemma":[0.9991369,0.0001600087,0.0004896328,0.0001014245,0.00009605224,0.00001597276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002518302,0.0001042421,0.0007646591,0.00001462814,0.00003240027,0.000004187978,0.002165559,0.0003423601,0.9925385,0.00001809122,0.0001636635,0.001333479],"study_design_scores_gemma":[0.001064097,0.001332894,0.002412405,0.000194479,0.00001478746,0.0001406129,0.000386505,0.000006876825,0.9936252,0.00002349797,0.0007368773,0.00006175544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954592,0.003113009,0.0007001035,0.0003804462,0.0002123673,0.0000967908,0.00001350485,0.000003152082,0.00002143008],"genre_scores_gemma":[0.9994119,0.0002841144,0.00008284111,0.00009091379,0.00003960808,0.000002757254,0.000003762594,0.000008172549,0.00007596734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003952666,"threshold_uncertainty_score":0.299392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008184044328591867,"score_gpt":0.2286570178651054,"score_spread":0.2204729735365135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}