{"id":"W2159798757","doi":"10.1128/jvi.79.7.3969-3978.2005","title":"Inhibition of RIG-I-Dependent Signaling to the Interferon Pathway during Hepatitis C Virus Expression and Restoration of Signaling by IKKε","year":2005,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Albert-Ludwigs-Universität Freiburg; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"TRIF; Biology; Innate immune system; Interferon; IκB kinase; Signal transduction; Cell biology; Phosphorylation; Ectopic expression; Kinase; RIG-I; Replicon; NS3; Toll-like receptor; NF-κB; Virology; Immune system; Hepatitis C virus; Immunology; Biochemistry; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001597184,0.0003032716,0.000200618,0.0001055743,0.0001105416,0.0001885068,0.0001919061,0.000161748,0.0007904431],"category_scores_gemma":[0.0001111187,0.0001016177,0.0002572153,0.0001067473,0.0002546284,0.0001492229,0.0001302535,0.0005283487,0.0002983729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002336105,"about_ca_system_score_gemma":0.0002769576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004577353,"about_ca_topic_score_gemma":0.0004828783,"domain_scores_codex":[0.9998416,0.00003488869,0.00001633059,0.00001895704,0.00003375229,0.00005445274],"domain_scores_gemma":[0.9999202,0.00001897002,0.00002213547,0.00001400618,0.000008126668,0.00001647512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001869801,0.00002955969,0.00005520224,0.00002949397,0.000002846666,0.0000209017,0.000009282505,0.00004136997,0.9989681,0.00006879387,0.00001568495,0.0005718102],"study_design_scores_gemma":[0.00001378795,0.0002163104,0.001079119,0.000003657219,0.000007074716,0.00008617716,0.000008577797,0.0004852847,0.9974768,0.00002355265,0.0005971909,0.000002485926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952062,0.001126826,0.002127773,0.00006456997,0.00003345839,0.00002850766,0.000173281,0.00004994812,0.001189301],"genre_scores_gemma":[0.9960529,0.0006012864,0.001616246,0.00003324632,0.000007747436,0.00004565648,0.0003172487,0.00001302568,0.001312646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007904431,"threshold_uncertainty_score":0.0026443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008184044328591867,"score_gpt":0.2286570178651054,"score_spread":0.2204729735365135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}