{"id":"W2159830267","doi":"10.2353/ajpath.2008.071081","title":"Neuraminidase-1, a Subunit of the Cell Surface Elastin Receptor, Desialylates and Functionally Inactivates Adjacent Receptors Interacting with the Mitogenic Growth Factors PDGF-BB and IGF-2","year":2008,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Receptor; Platelet-derived growth factor receptor; Elastin; Protein subunit; Neuraminidase; Cell surface receptor; Cell biology; Platelet-derived growth factor; Biology; Cell growth; Biochemistry; Growth factor; Genetics; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001986009,0.000523568,0.0002379949,0.0001816604,0.0001337613,0.0003014487,0.0002283573,0.0002693443,0.001273082],"category_scores_gemma":[0.0001893924,0.0001855733,0.0002874416,0.0001038955,0.0002609996,0.0002276668,0.0002384637,0.0004027013,0.0007235707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005273464,"about_ca_system_score_gemma":0.000221046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009072086,"about_ca_topic_score_gemma":0.001148301,"domain_scores_codex":[0.9998637,0.00002288845,0.00001056271,0.00002313189,0.00003107869,0.0000485181],"domain_scores_gemma":[0.9999212,0.00001571428,0.000023342,0.000009959994,0.00001130422,0.00001843673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001064644,0.000008247907,0.0002141334,0.00002451403,0.000006015935,0.00008001252,0.000009008261,0.0000319236,0.9977065,0.0001346044,0.00003363566,0.001644842],"study_design_scores_gemma":[0.00001128721,0.0001069013,0.003936883,0.000003978427,0.00001157299,0.0005068484,0.00002759281,0.0003291719,0.9919586,0.00006405341,0.003039718,0.00000339072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872589,0.004273671,0.00490007,0.0001737256,0.00006371425,0.00002404687,0.000211527,0.00004054914,0.003053802],"genre_scores_gemma":[0.9879155,0.002459513,0.002594926,0.00008470436,0.00002020546,0.00001570144,0.0005692731,0.00001445787,0.006325586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001273082,"threshold_uncertainty_score":0.004258931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009555880567361985,"score_gpt":0.2205684844601,"score_spread":0.211012603892738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}