{"id":"W2159830267","doi":"10.2353/ajpath.2008.071081","title":"Neuraminidase-1, a Subunit of the Cell Surface Elastin Receptor, Desialylates and Functionally Inactivates Adjacent Receptors Interacting with the Mitogenic Growth Factors PDGF-BB and IGF-2","year":2008,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Receptor; Platelet-derived growth factor receptor; Elastin; Protein subunit; Neuraminidase; Cell surface receptor; Cell biology; Platelet-derived growth factor; Biology; Cell growth; Biochemistry; Growth factor; Genetics; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002268888,0.0001527951,0.0002517429,0.00005630879,0.0001515358,0.000009822807,0.0002030201,0.00004859107,0.0000182045],"category_scores_gemma":[0.0004368991,0.00008687363,0.00006974776,0.0002028913,0.001031021,0.000010685,0.0001308361,0.0003039904,4.048909e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001834073,"about_ca_system_score_gemma":0.0001291084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005540601,"about_ca_topic_score_gemma":0.00003027014,"domain_scores_codex":[0.9987387,0.0004602852,0.0002364794,0.0001980491,0.0001661759,0.0002002799],"domain_scores_gemma":[0.9985914,0.0004239721,0.0004861388,0.0001498787,0.0002790243,0.00006958694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006355342,0.00006868024,0.2975602,0.000009287346,0.00009091237,0.00001333546,0.001056256,0.00004357613,0.6989116,0.000002741654,0.000222449,0.001385453],"study_design_scores_gemma":[0.001135776,0.005335432,0.305882,0.00004589864,0.00007283479,0.001691772,0.01184396,0.00001453907,0.6723242,0.00001734138,0.001381403,0.0002548971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979901,0.0008566501,0.0001723543,0.000729836,0.00009451172,0.0001101605,0.000005452052,0.000002019983,0.00003894482],"genre_scores_gemma":[0.9987924,0.0006443607,0.0003751387,0.00005432779,0.00004387451,0.000001899756,0.000003193238,0.00001902005,0.0000657756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02658744,"threshold_uncertainty_score":0.3798839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009555880567361985,"score_gpt":0.2205684844601,"score_spread":0.211012603892738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}