{"id":"W2159831861","doi":"10.1016/s0140-6736(07)60946-5","title":"Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial","year":2007,"lang":"en","type":"article","venue":"The Lancet","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":1315,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"","keywords":"Medicine; Vaccine trial; Cervical intraepithelial neoplasia; Cervical cancer; Vaccine efficacy; Vaccination; Interim analysis; Cohort; Clinical endpoint; Internal medicine; Cytology; Clinical trial; Gynecology; Oncology; Virology; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003582007,0.002426084,0.007300448,0.0006555314,0.0006227847,0.001360345,0.001611922,0.003320213,0.005396671],"category_scores_gemma":[0.003666512,0.001245298,0.003300795,0.0006049186,0.001954752,0.001561659,0.0005490567,0.003691657,0.001117883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009766016,"about_ca_system_score_gemma":0.00177014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001437516,"about_ca_topic_score_gemma":0.001719138,"domain_scores_codex":[0.9985146,0.0007982194,0.0001166968,0.0002341346,0.0001090132,0.0002273875],"domain_scores_gemma":[0.9980729,0.000816895,0.0003687142,0.0002061075,0.0001134006,0.0004220308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9905154,0.001802896,0.0001596585,0.0004430023,0.0005201272,0.00001554753,0.00003640991,0.0001478169,0.001007888,0.00003947527,0.000181418,0.005130396],"study_design_scores_gemma":[0.9502993,0.04790896,0.0005778672,0.00003306193,0.0004680655,0.00001336582,0.00001078538,0.0001726694,0.0002667796,0.00007115192,0.0001679115,0.00001013435],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839712,0.006915812,0.001403514,0.0006113275,0.001078698,0.003544343,0.001053466,0.0002274552,0.001194311],"genre_scores_gemma":[0.9849244,0.003245868,0.002355903,0.000902419,0.0005613843,0.00444923,0.0009598142,0.00005300549,0.002547953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007300448,"threshold_uncertainty_score":0.01894367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06427941154357125,"score_gpt":0.3983157518856838,"score_spread":0.3340363403421125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}