{"id":"W2159875179","doi":"10.1158/1078-0432.ccr-08-0405","title":"Tris (Dibenzylideneacetone) Dipalladium, a<i>N</i>-Myristoyltransferase-1 Inhibitor, Is Effective against Melanoma Growth<i>In vitro</i>and<i>In vivo</i>","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health; Emory University","keywords":"Tris; In vivo; Protein kinase B; Melanoma; Cancer research; PI3K/AKT/mTOR pathway; Phosphorylation; Signal transduction; Kinase; In vitro; Mechanism of action; Chemistry; Protein kinase A; Biology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002286536,0.0002478926,0.0004649621,0.000235668,0.0001879716,0.0000305811,0.000273316,0.0004177118,0.00005687383],"category_scores_gemma":[0.0005159722,0.0002431062,0.0001931711,0.0005250584,0.0005838439,0.00001402229,0.0001781069,0.0008049837,0.00001479643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001170831,"about_ca_system_score_gemma":0.0003630364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005938043,"about_ca_topic_score_gemma":0.000369622,"domain_scores_codex":[0.996269,0.0008968032,0.0007136899,0.0009187129,0.0005183232,0.0006834777],"domain_scores_gemma":[0.9986991,0.000322191,0.00006686458,0.000372168,0.0002346503,0.0003050619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003241976,0.0003512748,0.05212339,0.0001007128,0.00005477948,0.0002077228,0.0002172001,0.00003404974,0.9326797,0.00002516495,0.003266439,0.00769765],"study_design_scores_gemma":[0.00401935,0.0003878767,0.01727728,0.0001224118,0.000007213083,0.00001198726,0.00003510076,0.0001625095,0.961136,0.0001281618,0.01636194,0.000350192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990257,0.006770505,0.00007289481,0.0009601964,0.0001391539,0.0009074988,0.00006483788,0.00001562525,0.0008123486],"genre_scores_gemma":[0.9896864,0.007851639,0.0001195724,0.001004318,0.0005388843,0.000367992,0.00002867632,0.000043805,0.0003587671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03484611,"threshold_uncertainty_score":0.9913583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05516778673941028,"score_gpt":0.3757980825299887,"score_spread":0.3206302957905784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}