{"id":"W2159875179","doi":"10.1158/1078-0432.ccr-08-0405","title":"Tris (Dibenzylideneacetone) Dipalladium, a<i>N</i>-Myristoyltransferase-1 Inhibitor, Is Effective against Melanoma Growth<i>In vitro</i>and<i>In vivo</i>","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health; Emory University","keywords":"Tris; In vivo; Protein kinase B; Melanoma; Cancer research; PI3K/AKT/mTOR pathway; Phosphorylation; Signal transduction; Kinase; In vitro; Mechanism of action; Chemistry; Protein kinase A; Biology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006308826,0.0003417481,0.0001717535,0.0001982757,0.00008174843,0.0001314519,0.0001794542,0.0001233213,0.001086772],"category_scores_gemma":[0.00005226453,0.00009188307,0.0001779625,0.0001356381,0.0001238705,0.0000954616,0.00008872867,0.0003225272,0.0002647094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002629556,"about_ca_system_score_gemma":0.0002019035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008035283,"about_ca_topic_score_gemma":0.001889784,"domain_scores_codex":[0.999944,0.000005235894,0.000005062075,0.00001255217,0.00001885484,0.00001442211],"domain_scores_gemma":[0.999951,0.000005222092,0.00001862747,0.000002698258,0.000006390301,0.00001603222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002578567,0.00005267271,0.0001814195,0.0001133036,0.000009633972,0.00002455475,0.000002515764,0.0000652574,0.9952988,0.00003444735,0.00009014578,0.003869531],"study_design_scores_gemma":[0.0000411724,0.001056923,0.002296735,0.000006919435,0.00002887043,0.0001936428,0.00000626709,0.0002903454,0.9932173,0.00001564132,0.002843066,0.000003096499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705687,0.0192991,0.003167799,0.0001970738,0.00008079198,0.00008628078,0.0005982317,0.0003253127,0.005676755],"genre_scores_gemma":[0.9875603,0.006598912,0.001953345,0.00009646227,0.00001681434,0.00002746773,0.000751614,0.00002352464,0.00297157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001086772,"threshold_uncertainty_score":0.003635585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05516778673941028,"score_gpt":0.3757980825299887,"score_spread":0.3206302957905784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}