{"id":"W2159887222","doi":"10.1210/en.2014-1565","title":"Inactivation of Histone Deacetylase 1 (HDAC1) But Not HDAC2 Is Required for the Glucocorticoid-Dependent CCAAT/Enhancer-Binding Protein α (C/EBPα) Expression and Preadipocyte Differentiation","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; NOSM University; Health Canada","funders":"Canadian Institutes of Health Research","keywords":"Adipogenesis; Trichostatin A; HDAC1; Ccaat-enhancer-binding proteins; Histone deacetylase 2; Glucocorticoid receptor; Histone deacetylase; Biology; Transcription factor; Molecular biology; Internal medicine; Endocrinology; Chemistry; Glucocorticoid; Cancer research; Histone; Biochemistry; Adipose tissue; Medicine; Nuclear protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168408,0.0003818332,0.0003776667,0.0001717554,0.0002404704,0.0003724486,0.0002077286,0.0002121829,0.001440861],"category_scores_gemma":[0.00009296375,0.0002041035,0.0004933284,0.0001447487,0.0002662994,0.0001626198,0.0001685997,0.0006188246,0.0004719916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003654722,"about_ca_system_score_gemma":0.0003400808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001392385,"about_ca_topic_score_gemma":0.002811324,"domain_scores_codex":[0.9998589,0.000009852227,0.00001551705,0.00004379025,0.00003073946,0.00004122223],"domain_scores_gemma":[0.9999107,0.0000114581,0.00002998839,0.0000107808,0.000009172714,0.00002779807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009290037,0.00001597095,0.0002927395,0.00003381668,0.00000541562,0.00004185172,0.000009511999,0.0000307878,0.9984919,0.00005252482,0.0000341559,0.0008986104],"study_design_scores_gemma":[0.00002014385,0.0001082312,0.01208433,0.000004176641,0.00002051036,0.0002552051,0.00002389444,0.0004205882,0.9842715,0.00002799616,0.002757726,0.00000576818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844927,0.006425498,0.005438917,0.0002859519,0.0001452623,0.00003927882,0.0008927498,0.0001480001,0.002131575],"genre_scores_gemma":[0.9905828,0.002580838,0.002334412,0.000124443,0.00002982887,0.00003796818,0.0008714123,0.0000372853,0.003400932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001440861,"threshold_uncertainty_score":0.004820108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181736646884182,"score_gpt":0.3068163031777105,"score_spread":0.2886426384892923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}