{"id":"W2159887222","doi":"10.1210/en.2014-1565","title":"Inactivation of Histone Deacetylase 1 (HDAC1) But Not HDAC2 Is Required for the Glucocorticoid-Dependent CCAAT/Enhancer-Binding Protein α (C/EBPα) Expression and Preadipocyte Differentiation","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; NOSM University; Health Canada","funders":"Canadian Institutes of Health Research","keywords":"Adipogenesis; Trichostatin A; HDAC1; Ccaat-enhancer-binding proteins; Histone deacetylase 2; Glucocorticoid receptor; Histone deacetylase; Biology; Transcription factor; Molecular biology; Internal medicine; Endocrinology; Chemistry; Glucocorticoid; Cancer research; Histone; Biochemistry; Adipose tissue; Medicine; Nuclear protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002138285,0.0002014818,0.0002604688,0.0001077391,0.000184923,0.00001832548,0.0002254894,0.0001771346,0.00002512895],"category_scores_gemma":[0.0004725868,0.0001673416,0.0000883281,0.00007147877,0.0001967122,0.00001512348,0.0002051101,0.0001640989,0.0000100302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008766773,"about_ca_system_score_gemma":0.00006843657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008438742,"about_ca_topic_score_gemma":0.00003651283,"domain_scores_codex":[0.9982787,0.0001749899,0.0003803167,0.0005158883,0.000233016,0.000417032],"domain_scores_gemma":[0.9988462,0.0001287453,0.0002757256,0.0005280074,0.0001561294,0.00006519492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005516461,0.00007544307,0.00004925428,0.00009592366,0.00004839047,7.299553e-7,0.0001278231,0.0000144893,0.9932145,0.0002225117,0.000424646,0.005174615],"study_design_scores_gemma":[0.001629825,0.0005568239,0.0002948116,0.00003834484,0.00002923251,0.00001492358,0.00007519696,0.0004979834,0.9927497,0.00004489219,0.003898912,0.0001693414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882674,0.0003453395,0.009454574,0.0003850354,0.000190034,0.001159205,0.00003830287,0.00001831741,0.0001418282],"genre_scores_gemma":[0.9956813,0.0001103196,0.0004724095,0.00002845293,0.0001808676,0.0004291243,0.00009224614,0.00003643735,0.002968779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008982165,"threshold_uncertainty_score":0.6823991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181736646884182,"score_gpt":0.3068163031777105,"score_spread":0.2886426384892923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}