{"id":"W2159919643","doi":"10.1093/nar/gkt623","title":"Analysis of epigenetic stability and conversions in Saccharomyces cerevisiae reveals a novel role of CAF-I in position-effect variegation","year":2013,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Public Health Agency of Canada","funders":"Natural Sciences and Engineering Research Council of Canada; Japan Society for the Promotion of Science; Canadian Institutes of Health Research","keywords":"Position effect; Biology; Heterochromatin; Epigenetics; Euchromatin; Genetics; Gene silencing; Saccharomyces cerevisiae; Variegation (histology); Chromatin; Psychological repression; Heterochromatin protein 1; Histone; Gene; Locus (genetics); Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001205801,0.0001952868,0.0001539472,0.0002186593,0.0001124344,0.0002592697,0.0001696286,0.0001225834,0.0002715952],"category_scores_gemma":[0.0002120236,0.0001281185,0.0002432758,0.0002536086,0.0001304523,0.0001413336,0.0001569601,0.0002722439,0.00005991529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004327245,"about_ca_system_score_gemma":0.0001474738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004502142,"about_ca_topic_score_gemma":0.004377078,"domain_scores_codex":[0.9999492,0.000006931767,0.000003888699,0.00001655604,0.00001504276,0.000008350175],"domain_scores_gemma":[0.9999032,0.00002480955,0.00002511694,0.00002107503,0.000009828695,0.00001602061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002028794,0.00005815376,0.01600871,0.00003593131,0.00003855142,0.00006243058,0.00003256548,0.01678894,0.9587736,0.0008826849,0.00003467387,0.007080891],"study_design_scores_gemma":[0.00001499346,0.0003197076,0.05792863,0.00000431345,0.00004320385,0.0001971154,0.00007030342,0.1902857,0.7497091,0.000652113,0.0007470405,0.00002781974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995852,0.0001113772,0.003736837,0.000007664851,9.557898e-7,0.000002380998,0.0001042727,0.00003280377,0.0001517568],"genre_scores_gemma":[0.9983633,0.00009471659,0.001287435,0.000002012159,3.611799e-7,0.000002113129,0.0001204818,0.000007965875,0.0001215951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004502142,"threshold_uncertainty_score":0.008951902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135021334512829,"score_gpt":0.2855639915698877,"score_spread":0.2720618581186047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}