{"id":"W2159938446","doi":"10.1074/jbc.m004125200","title":"Characterization of the Ca2+-binding Sites of Annexin II Tetramer","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute","keywords":"Heterotetramer; Tetramer; Binding site; Annexin; Chemistry; Phospholipid; Annexin A2; Protein subunit; Actin; Biochemistry; Wild type; Mutant; Mutagenesis; Biophysics; Biology; In vitro; Enzyme; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001615893,0.00009211054,0.0001827731,0.000009849091,0.00004541341,0.000004490347,0.0002410762,0.0001919815,0.0003878897],"category_scores_gemma":[0.0001039042,0.00005330665,0.0001869028,0.000082537,0.0001318025,0.000003801807,0.0000563178,0.0001310824,6.142598e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006131291,"about_ca_system_score_gemma":0.0000383586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000119225,"about_ca_topic_score_gemma":1.876636e-7,"domain_scores_codex":[0.9992822,0.0000286899,0.0003615879,0.0001020792,0.0001151381,0.0001102625],"domain_scores_gemma":[0.999342,0.000008673564,0.0003492871,0.0001447484,0.0001138559,0.00004143238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009433889,0.0001030885,0.005748474,0.00001795897,0.00002903972,0.000001129844,0.000015831,0.000005438008,0.9924778,0.000002508511,0.00005946678,0.001444927],"study_design_scores_gemma":[0.000220306,0.0002504852,0.01101858,0.00004003239,0.00001020131,0.00003703561,0.00002717366,0.000002812186,0.9829945,0.00001993443,0.005313417,0.00006552648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987018,0.0002122214,0.00001408295,0.0000938607,0.00003009143,0.0000410557,0.00003111787,0.000001587354,0.0008742154],"genre_scores_gemma":[0.9987577,0.0002391717,0.00009918315,0.00005352559,0.0002105194,8.971672e-7,0.00002357647,0.00000449749,0.0006109824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009483303,"threshold_uncertainty_score":0.4247121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01438105118853498,"score_gpt":0.2332994774207015,"score_spread":0.2189184262321666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}