{"id":"W2159940514","doi":"10.1371/journal.pgen.1000705","title":"Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance","year":2009,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":336,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Aneuploidy; Biology; Isochromosome; Fluconazole; Antifungal drug; Genetics; Candida albicans; Drug resistance; Chromosome; Karyotype; Microbiology; Gene; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002112961,0.0001731805,0.0002749866,0.0003500132,0.0002059785,0.0004157186,0.000160151,0.0003354501,0.0007184716],"category_scores_gemma":[0.0005319445,0.0001606827,0.0001751706,0.0002257994,0.0001605965,0.0002935399,0.0003654161,0.0004879753,0.0001328971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002519894,"about_ca_system_score_gemma":0.0001564871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217219,"about_ca_topic_score_gemma":0.001392095,"domain_scores_codex":[0.9997293,0.00005399315,0.00002448909,0.00007280471,0.00007727923,0.00004224231],"domain_scores_gemma":[0.9996032,0.00009428485,0.0001236692,0.00004697939,0.00007377649,0.00005814696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001147991,0.000032584,0.005629489,0.00001824956,0.000009920281,0.00006807762,0.00005120102,0.0001001955,0.9908828,0.00004963003,0.00002855648,0.003014473],"study_design_scores_gemma":[0.00001661943,0.001421361,0.4776223,0.00002575614,0.0000468032,0.000884655,0.0003313572,0.002557732,0.5141338,0.000185025,0.002732769,0.00004194916],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974956,0.0006870445,0.001013529,0.00003466611,0.000005487491,0.00001540354,0.0001855622,0.00001771156,0.000545005],"genre_scores_gemma":[0.9979987,0.0003255428,0.0007189465,0.00003871666,0.00000452643,0.00001778386,0.0002702162,0.000007295356,0.0006183404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001217219,"threshold_uncertainty_score":0.002420306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009809965417842195,"score_gpt":0.2415448772713579,"score_spread":0.2317349118535157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}