{"id":"W2159943759","doi":"10.1001/jama.283.4.492","title":"Nucleoside Analogs Plus Ritonavir in Stable Antiretroviral Therapy–Experienced HIV-Infected Children<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>","year":2000,"lang":"en","type":"article","venue":"JAMA","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, University of North Carolina at Chapel Hill; National Institute of Allergy and Infectious Diseases; National Institute of Child Health and Human Development; Abbott Laboratories; University of California, San Diego; University of North Carolina at Chapel Hill; National Institutes of Health; Bristol-Myers Squibb; York University; University of Pittsburgh; University of Minnesota; Harvard University; Bunning Food Allergy Institute, Ann and Robert H. Lurie Children's Hospital of Chicago; Children's Hospital of Philadelphia","keywords":"Medicine; Ritonavir; Regimen; Stavudine; Lamivudine; Zidovudine; Indinavir; Internal medicine; Didanosine; Randomized controlled trial; Protease inhibitor (pharmacology); Clinical trial; Nelfinavir; Viral load; Gastroenterology; Immunology; Viral disease; Antiretroviral therapy; Human immunodeficiency virus (HIV); Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001001145,0.0005858275,0.002692514,0.000432546,0.000179057,0.0001287381,0.0002367252,0.000319076,0.00693483],"category_scores_gemma":[0.0003825593,0.0004152911,0.0006530894,0.0007037706,0.0002182303,0.00028736,0.00004079038,0.0003839691,0.0009214066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003344456,"about_ca_system_score_gemma":0.0004276168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000224958,"about_ca_topic_score_gemma":0.0001007543,"domain_scores_codex":[0.9961135,0.0004669777,0.001212488,0.0006981011,0.0007293917,0.0007795123],"domain_scores_gemma":[0.998336,0.000428574,0.0002672617,0.0005664902,0.0001298425,0.0002717852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9583383,0.00141477,0.008413344,0.00001547047,0.001088659,0.0002701427,0.002736869,0.00001673148,0.003633576,0.0002182038,0.007183242,0.01667066],"study_design_scores_gemma":[0.9769351,0.0004414116,0.009486528,0.0001398371,0.0002524892,0.00002889389,0.00005480717,0.0009300957,0.002253171,0.00006451747,0.008949813,0.000463333],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595136,0.001227569,0.0000150314,0.001403506,0.0002683462,0.006335843,0.00002082868,0.0002364521,0.03097881],"genre_scores_gemma":[0.9480749,0.00117102,0.0004515956,0.0004949314,0.000387287,0.0008640781,0.0003138233,0.00007798812,0.04816438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01859677,"threshold_uncertainty_score":0.9998565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007770306467116419,"score_gpt":0.2457569508733633,"score_spread":0.2379866444062469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}