{"id":"W2159962592","doi":"10.1373/clinchem.2004.035907","title":"Direct Multiplex Assay of Lysosomal Enzymes in Dried Blood Spots for Newborn Screening","year":2004,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":333,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Hope Foundation; Hunter's Hope Foundation","keywords":"Dried blood spot; Spots; Newborn screening; Enzyme; Dried blood; Multiplex; Enzyme replacement therapy; Lysosomal storage disease; Fabry disease; Chemistry; Chromatography; Biochemistry; Molecular biology; Medicine; Biology; Disease; Pathology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00111223,0.0009827178,0.0006026553,0.001548398,0.0002578896,0.000577314,0.0004872169,0.0006141502,0.00138429],"category_scores_gemma":[0.00125577,0.0003196815,0.0002935102,0.0007064635,0.000317758,0.0002786971,0.0005362488,0.00058173,0.001025234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002888344,"about_ca_system_score_gemma":0.0002375324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000265088,"about_ca_topic_score_gemma":0.0005082997,"domain_scores_codex":[0.9987094,0.0002657688,0.0001152977,0.000376633,0.0004310449,0.0001018435],"domain_scores_gemma":[0.9992791,0.0002277273,0.0001425705,0.00007904298,0.0001652344,0.0001064043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003381233,0.0001375641,0.01266446,0.0001784775,0.00007323247,0.0002704966,0.00007722125,0.0003036314,0.9608692,0.0001917367,0.0005516215,0.02434426],"study_design_scores_gemma":[0.00003167613,0.0005980946,0.01615673,0.00003335649,0.0001078101,0.002117968,0.00003528821,0.005180079,0.971733,0.0001755864,0.003798756,0.00003160593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6845482,0.007201786,0.2973665,0.0002584576,0.0003018284,0.001041973,0.003580632,0.001938316,0.003762242],"genre_scores_gemma":[0.6291738,0.002746158,0.3594356,0.0002623773,0.0001372417,0.0008134991,0.003467072,0.00006624265,0.00389811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001548398,"threshold_uncertainty_score":0.005882144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06464975133579742,"score_gpt":0.3839865470355851,"score_spread":0.3193367956997877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}