{"id":"W2160001764","doi":"10.1158/0008-5472.can-04-2910","title":"The G-Quadruplex-Interactive Molecule BRACO-19 Inhibits Tumor Growth, Consistent with Telomere Targeting and Interference with Telomerase Function","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":566,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Albert-Ludwigs-Universität Freiburg","keywords":"Telomerase; Telomere; Biology; Telomerase reverse transcriptase; Molecular biology; DNA damage; Cancer research; Cell biology; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000920777,0.000373503,0.0002284091,0.0001968549,0.0001205658,0.0002025477,0.0001966627,0.0001816149,0.001557608],"category_scores_gemma":[0.00007235038,0.0001003275,0.0001329475,0.0001349418,0.000208573,0.0001354355,0.0001083652,0.0004478163,0.0003424797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002032901,"about_ca_system_score_gemma":0.0001649511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005172143,"about_ca_topic_score_gemma":0.00123476,"domain_scores_codex":[0.9999146,0.00001252049,0.000005151574,0.00002013569,0.00002639855,0.00002126366],"domain_scores_gemma":[0.9999273,0.00001426829,0.00002037653,0.00001022885,0.00001143079,0.00001644166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000732823,0.00001998606,0.00005232922,0.00002103716,0.000002275591,0.00001053352,0.000003099308,0.000027428,0.9986451,0.00003349625,0.0000209825,0.001090333],"study_design_scores_gemma":[0.0000144015,0.0006086651,0.001162602,0.000002009483,0.000007182837,0.0001051132,0.000003246302,0.0001915197,0.9965334,0.000009433038,0.001361,0.000001559839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870409,0.005078777,0.003209952,0.0001175554,0.0000532097,0.00008312255,0.0006104948,0.0001796096,0.003626382],"genre_scores_gemma":[0.9915071,0.002078749,0.002223338,0.00004492051,0.00001587688,0.00006567487,0.0008046658,0.00002032314,0.003239378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001557608,"threshold_uncertainty_score":0.005210757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01799993790488197,"score_gpt":0.3310384391677136,"score_spread":0.3130385012628316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}