{"id":"W2160014514","doi":"10.1007/8904_2015_491","title":"Detailed Biochemical and Bioenergetic Characterization of FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion","year":2015,"lang":"en","type":"article","venue":"JIMD Reports","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Newborn Screening Ontario; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"Bioenergetics; Mitochondrial DNA; Characterization (materials science); Chemistry; Cell biology; Biology; Mitochondrion; Biochemistry; Nanotechnology; Materials science; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002065768,0.0001406429,0.000197065,0.00006626321,0.00003327709,0.00001192141,0.00005022712,0.0003129159,0.0000329438],"category_scores_gemma":[0.0003583004,0.0001307398,0.00006608683,0.0001141707,0.0001193853,0.00000659441,0.00004724367,0.00007879084,0.000005022512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001024134,"about_ca_system_score_gemma":0.00009998056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007020564,"about_ca_topic_score_gemma":0.000005829683,"domain_scores_codex":[0.998744,0.00009747939,0.0004577063,0.000394616,0.0001502237,0.0001559943],"domain_scores_gemma":[0.9990886,0.00000590786,0.0002887122,0.0003042655,0.0001740732,0.0001384543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001095917,0.00004439439,0.008798075,0.00001197794,0.00001815675,0.0000294911,0.00005750531,0.000003228414,0.990125,0.00002869213,0.0005303333,0.0002435588],"study_design_scores_gemma":[0.0007705119,0.0003725859,0.006617389,0.00001943046,0.00004725591,0.0008002116,0.00002632684,0.00004540972,0.980108,0.0001860007,0.01079152,0.0002153865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954992,0.0002211205,0.00196368,0.00009104092,0.001671134,0.000199368,0.000006109314,0.00002147068,0.000326905],"genre_scores_gemma":[0.9977714,0.00006452356,0.0005545729,0.00007562249,0.0003559118,0.00002026967,0.000547953,0.00001802129,0.0005916927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01026119,"threshold_uncertainty_score":0.5331416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087455610178831,"score_gpt":0.22668587755944,"score_spread":0.2158113214576517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}