{"id":"W2160034397","doi":"10.1186/gb-2013-14-2-r11","title":"Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling","year":2013,"lang":"en","type":"article","venue":"Genome biology","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":315,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University; Simon Fraser University; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Biotechnology and Biological Sciences Research Council; Chang Gung Medical Foundation; Science Foundation Ireland; Broad Institute; Natural Sciences and Engineering Research Council of Canada; Universität Wien","keywords":"Biology; Multicellular organism; Genome; Horizontal gene transfer; Gene; Evolutionary biology; Genetics; Lineage (genetic)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278756,0.0001759767,0.0003125231,0.0001152112,0.00005706254,0.00000887767,0.0001786091,0.0002469902,0.00007721946],"category_scores_gemma":[0.00001763461,0.0001470691,0.00008382091,0.0001017722,0.0003195395,0.000006684605,0.0001092101,0.00008700857,0.00001062121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001944393,"about_ca_system_score_gemma":0.00007138302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006583873,"about_ca_topic_score_gemma":0.00001482273,"domain_scores_codex":[0.9987341,0.0001034652,0.0003420001,0.0003788486,0.00008564684,0.0003558999],"domain_scores_gemma":[0.9992576,0.00001878202,0.0000754074,0.0002604289,0.0002772387,0.0001105972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001003475,0.00004124639,0.005782214,0.00004047892,0.00007287325,0.000004025382,0.0001264076,0.00001393582,0.9934009,0.0002331506,0.000007420357,0.0001770168],"study_design_scores_gemma":[0.000916451,0.001141291,0.1298605,0.00001043414,0.00002577384,0.00003694116,0.00005964439,0.00001240369,0.8655862,0.0002421012,0.001873622,0.0002346302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931082,0.005479695,0.0007255538,0.0001192197,0.00006895132,0.0003179721,0.00007248395,0.000005877968,0.0001020423],"genre_scores_gemma":[0.9986993,0.0005387983,0.0002283772,0.00002628681,0.000184325,0.00001609381,0.00008796324,0.00001975836,0.0001990823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1278147,"threshold_uncertainty_score":0.5997304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116664587266437,"score_gpt":0.2306150627881087,"score_spread":0.2194484169154443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}