{"id":"W2160042256","doi":"10.2337/db13-1524","title":"Perforin Is a Novel Immune Regulator of Obesity-Related Insulin Resistance","year":2014,"lang":"en","type":"article","venue":"Diabetes","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Perforin; Insulin resistance; Biology; CD8; Cytotoxic T cell; Endocrinology; Internal medicine; Immune system; T cell; Glucose homeostasis; Adipose tissue; Insulin; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001505093,0.0004910013,0.0002539723,0.0003293498,0.0001488054,0.0005566934,0.0001997282,0.0003965117,0.0006972781],"category_scores_gemma":[0.0002526579,0.0001038263,0.0001876365,0.0002255219,0.0002796828,0.0003895966,0.0003776914,0.0006052966,0.0002039996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002459996,"about_ca_system_score_gemma":0.0001046098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007102719,"about_ca_topic_score_gemma":0.00004761948,"domain_scores_codex":[0.9999063,0.00001622462,0.000007973462,0.00002965565,0.00001962682,0.00002017133],"domain_scores_gemma":[0.9998958,0.00001090859,0.00005573394,0.000004516846,0.000009480621,0.00002337841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001762187,0.0001176836,0.01291121,0.0004379333,0.00009403993,0.005445986,0.00007981918,0.0005524914,0.9302557,0.001782022,0.001018975,0.04554181],"study_design_scores_gemma":[0.001208652,0.004275743,0.2888997,0.0004576175,0.0008419856,0.07922624,0.0006249315,0.009064245,0.5211793,0.01068379,0.0833862,0.0001516789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9505549,0.03940699,0.00520941,0.001283724,0.0002192754,0.00003978754,0.0002372378,0.0002191038,0.002829615],"genre_scores_gemma":[0.990484,0.006591152,0.001186073,0.0001761959,0.0001140001,0.00001912702,0.0002543105,0.00001162347,0.001163637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006972781,"threshold_uncertainty_score":0.002332628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005566971409116291,"score_gpt":0.1922474001747579,"score_spread":0.1866804287656416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}