{"id":"W2160052005","doi":"10.1074/jbc.m409159200","title":"Neural Cell Adhesion Molecule (N-CAM) Homophilic Binding Mediated by the Two N-terminal Ig Domains Is Influenced by Intramolecular Domain-Domain Interactions","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"Transfection; Extracellular; Cell biology; Plasma protein binding; Binding site; Chemistry; Binding domain; Antibody; Biophysics; Cell adhesion; Cell; Biology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001389408,0.0002677954,0.0001820624,0.0001098396,0.0001569328,0.0002879369,0.000188363,0.0002370618,0.0007932218],"category_scores_gemma":[0.0002153961,0.000102779,0.0002313787,0.0001120664,0.0002407349,0.0001406682,0.0002372303,0.0003351584,0.0002528327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002768742,"about_ca_system_score_gemma":0.0001466034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007342796,"about_ca_topic_score_gemma":0.001335537,"domain_scores_codex":[0.9997581,0.00005827044,0.00001898183,0.00004929,0.00006660039,0.00004885668],"domain_scores_gemma":[0.999912,0.00002628087,0.00002067855,0.00001141869,0.00001217813,0.00001746078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000166537,0.000005872451,0.0001385652,0.00001043572,0.000002487729,0.00001886108,0.000004118041,0.00001696255,0.9993786,0.00002590447,0.000005521984,0.0003759555],"study_design_scores_gemma":[0.000008146238,0.00008133642,0.01468416,0.000007667248,0.0000157027,0.0001804672,0.00001443135,0.001090709,0.9831269,0.0000344385,0.0007525522,0.000003473451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993975,0.000997095,0.003310048,0.00002554487,0.00001093509,0.00001376821,0.0000447298,0.00002063654,0.001602212],"genre_scores_gemma":[0.9971299,0.0003760011,0.00178014,0.00003412701,0.000003688924,0.00001976126,0.00006744144,0.000004346839,0.0005847504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007932218,"threshold_uncertainty_score":0.002653599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01702736779767806,"score_gpt":0.3015045853629434,"score_spread":0.2844772175652653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}