{"id":"W2160065387","doi":"10.1128/mcb.05318-11","title":"The RPB2 Flap Loop of Human RNA Polymerase II Is Dispensable for Transcription Initiation and Elongation","year":2011,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; RNA polymerase II; Transcription factor II B; Cell biology; Transcription (linguistics); Molecular biology; Elongation factor; Terminator (solar); RNA polymerase; Termination factor; RNA; Genetics; Gene; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001541673,0.0004251348,0.0003908307,0.0002151487,0.0001889552,0.0004430168,0.0002843829,0.0002262207,0.0015222],"category_scores_gemma":[0.000298233,0.0002486942,0.0003274369,0.0001365609,0.0002352062,0.0001647532,0.0002622273,0.0003983178,0.001387698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001825042,"about_ca_system_score_gemma":0.0002620022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000516002,"about_ca_topic_score_gemma":0.0005117823,"domain_scores_codex":[0.9997467,0.00004185268,0.0000210239,0.00006957372,0.00008457529,0.00003629008],"domain_scores_gemma":[0.9997057,0.00008271111,0.00005947852,0.00005581142,0.0000232955,0.0000729751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001383238,0.00001546448,0.0004089653,0.00003158113,0.000005309014,0.000107102,0.00001126325,0.0000826806,0.9971817,0.00005725883,0.00005509192,0.001905196],"study_design_scores_gemma":[0.00005279095,0.0002550406,0.01975016,0.00002320717,0.00002093898,0.001656154,0.00004323078,0.001528547,0.9699953,0.000177196,0.006481591,0.00001595497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928405,0.002142828,0.002725618,0.00006911335,0.00002558794,0.00001586499,0.0007256073,0.0002249849,0.00122987],"genre_scores_gemma":[0.995887,0.0002576051,0.001166157,0.00003707825,0.00001295563,0.00002116595,0.0015047,0.00006639897,0.001046937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0015222,"threshold_uncertainty_score":0.005092323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02000218365127909,"score_gpt":0.2620905353614566,"score_spread":0.2420883517101775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}