{"id":"W2160074417","doi":"10.1091/mbc.e07-04-0394","title":"Distinct Functions for Arf Guanine Nucleotide Exchange Factors at the Golgi Complex: GBF1 and BIGs Are Required for Assembly and Maintenance of the Golgi Stack and<i>trans</i>-Golgi Network, Respectively","year":2007,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Universität Zürich; Fondation pour la Recherche Médicale; University of Alberta","keywords":"COPI; Golgi apparatus; Guanine nucleotide exchange factor; COPII; Biology; Cell biology; Golgi membrane; Endoplasmic reticulum; Brefeldin A; ADP ribosylation factor; Signal transducing adaptor protein; Gene knockdown; GTPase; Secretory pathway; Biochemistry; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004947212,0.0002270866,0.0002792875,0.00002412025,0.0002790124,0.000008787089,0.0002402202,0.0002008841,0.000004766497],"category_scores_gemma":[0.00007438615,0.0001331904,0.0002132103,0.0001008985,0.000692985,0.000003936467,0.0001525633,0.00009866255,9.570453e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000161733,"about_ca_system_score_gemma":0.00002245425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004265558,"about_ca_topic_score_gemma":0.0008871436,"domain_scores_codex":[0.9987507,0.0001094958,0.0003153914,0.0004044982,0.0000797417,0.0003401266],"domain_scores_gemma":[0.9990003,0.0001072418,0.0002926889,0.0004180309,0.0001242287,0.00005749039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004720255,0.00003533325,0.01934412,0.0001045915,0.00008519894,5.697603e-7,0.0001185947,0.00001898977,0.9790491,0.0001977576,0.0004164579,0.000157297],"study_design_scores_gemma":[0.002046808,0.0006856855,0.1540088,0.00005913883,0.0002781351,0.00001441606,0.0003182556,0.0001547108,0.7695064,0.0008900582,0.07171723,0.0003203899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9398462,0.002893942,0.0550839,0.0006282904,0.0001651413,0.0008698118,0.0003613827,0.000006418858,0.0001449561],"genre_scores_gemma":[0.9980565,0.0001839711,0.000294479,0.0001834667,0.00006971159,0.00002463692,0.0004269633,0.00002945345,0.0007308345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2095427,"threshold_uncertainty_score":0.5431347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773940336834913,"score_gpt":0.2425272284950095,"score_spread":0.2247878251266604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}