{"id":"W2160091872","doi":"10.1126/science.288.5465.483","title":"Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation <i>tau</i>","year":2000,"lang":"en","type":"article","venue":"Science","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":866,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Mental Health; Howard Hughes Medical Institute","keywords":"Biology; Mutant; Synteny; Genetics; Circadian rhythm; Locus (genetics); Positional cloning; Hamster; Allele; Molecular biology; Wild type; Mutation; Phenotype; Gene; Genome; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001236518,0.0002476639,0.00009924562,0.0002999773,0.0001772812,0.0002056481,0.0002752534,0.0001730143,0.0007970742],"category_scores_gemma":[0.0001631908,0.0001435696,0.000192926,0.0001536214,0.0002085321,0.0001044973,0.0002705163,0.0003473643,0.0004384195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003577092,"about_ca_system_score_gemma":0.0002330276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008906425,"about_ca_topic_score_gemma":0.002048421,"domain_scores_codex":[0.9999083,0.00001054114,0.00001200916,0.0000256782,0.00002640619,0.00001689219],"domain_scores_gemma":[0.9998633,0.00001552474,0.00005000658,0.00002048769,0.00001487708,0.00003577235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000257451,0.000009246078,0.000238827,0.00001193626,0.000002754062,0.00007855119,0.00001621917,0.00002808197,0.9981805,0.0002925793,0.00002300665,0.001092642],"study_design_scores_gemma":[0.00001927713,0.0001600007,0.02292495,0.00001442408,0.0000351822,0.001300709,0.00004413481,0.001021748,0.9628932,0.0001908968,0.01138692,0.000008579003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878563,0.0006515655,0.008151454,0.0001015337,0.00003051685,0.00005014167,0.0008279757,0.00005359593,0.002276927],"genre_scores_gemma":[0.982206,0.0007829203,0.009080827,0.00004160389,0.00001316504,0.00003991563,0.003408506,0.0000472707,0.004379841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008906425,"threshold_uncertainty_score":0.002666414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301966779586024,"score_gpt":0.21668897048525,"score_spread":0.2036693026893897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}