{"id":"W2160107157","doi":"10.1002/bip.10374","title":"Structure–activity relationships of de novo designed cyclic antimicrobial peptides based on gramicidin S","year":2003,"lang":"en","type":"article","venue":"Biopolymers","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences","keywords":"Gramicidin S; Peptide; Chemistry; Antimicrobial; Cyclic peptide; Amino acid; Antimicrobial peptides; Residue (chemistry); Gramicidin; Stereochemistry; Lysine; Peptide sequence; Beta sheet; Aromatic amino acids; Biochemistry; Membrane; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002323333,0.0002528714,0.0003322346,0.00019975,0.0003099006,0.0000165788,0.0001608678,0.0003282381,0.000307492],"category_scores_gemma":[0.0001651223,0.0002379321,0.0001659746,0.0002068499,0.0004895793,0.0000965764,0.00001805825,0.0003542205,0.0000476046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006892513,"about_ca_system_score_gemma":0.0001602197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002343844,"about_ca_topic_score_gemma":0.0000429249,"domain_scores_codex":[0.9984815,0.0004661698,0.0002543758,0.0003140092,0.00004223634,0.0004416904],"domain_scores_gemma":[0.9991404,0.0002924462,0.0002010483,0.0002966466,0.00003568835,0.00003378769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002506117,0.0001674857,0.006226316,0.00002383506,0.00006601905,0.000003043641,0.0001208331,0.0001315394,0.9898032,0.001871791,0.0008109481,0.0005243643],"study_design_scores_gemma":[0.001001818,0.0001571775,0.004445684,0.00004931532,0.00004903699,0.00003657343,0.0001609042,0.00001095469,0.9932629,0.0001127567,0.000457855,0.0002549864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956754,0.0001287019,0.001525386,0.0001638521,0.0003771157,0.0001946522,0.0001438168,0.00006497452,0.001726122],"genre_scores_gemma":[0.9982418,0.00001236174,0.0008071279,0.0002220162,0.00001900959,0.000003281051,0.00004650002,0.00002927409,0.0006185778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003459725,"threshold_uncertainty_score":0.9702588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0177758100424062,"score_gpt":0.2284485164275524,"score_spread":0.2106727063851462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}