{"id":"W2160119714","doi":"10.3390/biology2030976","title":"The Role of Nuclear Bodies in Gene Expression and Disease","year":2013,"lang":"en","type":"article","venue":"Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Institute of Human Development, Child and Youth Health; Hospital for Sick Children; University of British Columbia; National Institutes of Health; Michael Smith Health Research BC","keywords":"Biology; Cajal body; Transcription factories; Nucleolus; Ribosome biogenesis; Gene expression; Cell biology; Stress granule; Histone; Cell nucleus; Genetics; Spliceosome; Gene; RNA; RNA splicing; Ribosome; Transcriptional regulation; Messenger RNA; Nucleus; Translation (biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005997938,0.00003682361,0.0000463386,0.00001228408,0.00003863243,0.000005597811,0.0000740024,0.0000401725,0.000008186691],"category_scores_gemma":[0.000106199,0.00002258443,0.00001418961,0.00001051419,0.000104915,0.000001211247,0.0001012246,0.00002763256,0.000003688463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001598608,"about_ca_system_score_gemma":0.00001357153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007432654,"about_ca_topic_score_gemma":0.00001207578,"domain_scores_codex":[0.999653,0.00004340231,0.00006690386,0.00009786927,0.00001965143,0.0001192046],"domain_scores_gemma":[0.9997771,0.00001302095,0.00001783246,0.0001175764,0.00001827185,0.00005623671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000383944,0.00000730541,0.03445786,0.000002010863,0.000002985228,2.009048e-7,0.00001010315,3.769429e-7,0.9609282,0.0002039226,0.0002652892,0.004083339],"study_design_scores_gemma":[0.0006630049,0.0004049936,0.1746199,0.00001749453,0.000003474481,0.000003274348,0.0004082847,0.0004288583,0.7524822,0.006512249,0.06428459,0.0001716595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956787,0.00377013,0.000004933998,0.0002262202,0.0000119661,0.00007314619,0.000002780914,0.000001499926,0.0002306528],"genre_scores_gemma":[0.9988421,0.0008089706,0.0001016438,0.00004897888,0.00002749248,0.00001182503,0.000006988178,0.000003599238,0.0001483586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.208446,"threshold_uncertainty_score":0.09209664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005773556856783765,"score_gpt":0.2427405943285704,"score_spread":0.2369670374717866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}