{"id":"W2160120519","doi":"10.1016/s1470-2045(09)70162-7","title":"Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial","year":2009,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":591,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Sunitinib; Medicine; Discontinuation; Renal cell carcinoma; Expanded access; Internal medicine; Adverse effect; Population; Clinical trial; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007876682,0.0001556765,0.0008280139,0.00006327081,0.00007116142,0.00000956851,0.00016886,0.00006995136,0.00003155884],"category_scores_gemma":[0.0001209299,0.00009560887,0.00009667951,0.0001014825,0.0001223872,0.00006671121,0.00003585018,0.0001404931,0.000001994345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009331224,"about_ca_system_score_gemma":0.0001527567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004318222,"about_ca_topic_score_gemma":0.00001621699,"domain_scores_codex":[0.9986795,0.0002803303,0.000363137,0.0002080117,0.00013388,0.0003350932],"domain_scores_gemma":[0.9984837,0.000694307,0.0001989251,0.000420387,0.00007386503,0.0001288631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8147171,0.008446345,0.006640718,0.0006303372,0.0004986963,0.0002985008,0.006070517,0.00006768457,0.03855073,0.005351483,0.005956104,0.1127718],"study_design_scores_gemma":[0.5271562,0.0620923,0.3197156,0.00006445928,0.002365866,0.0005392972,0.0006510979,0.0002370101,0.05854386,0.001746266,0.02646053,0.0004274462],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885221,0.0005971067,0.0001679439,0.002397887,0.0001298578,0.001657727,0.00002531176,0.00002515429,0.006476902],"genre_scores_gemma":[0.9964422,0.00009918619,0.001691823,0.0007691712,0.0006148804,0.00005140209,0.00006272979,0.00001462619,0.0002539621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3130749,"threshold_uncertainty_score":0.3898817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1222978448838388,"score_gpt":0.3952200405295618,"score_spread":0.272922195645723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}