{"id":"W2160120519","doi":"10.1016/s1470-2045(09)70162-7","title":"Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial","year":2009,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":591,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Sunitinib; Medicine; Discontinuation; Renal cell carcinoma; Expanded access; Internal medicine; Adverse effect; Population; Clinical trial; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002599513,0.001320764,0.003265645,0.0003209898,0.00044577,0.001105928,0.0005742629,0.001561552,0.004776008],"category_scores_gemma":[0.002864769,0.0004420968,0.002335503,0.0004023318,0.001065011,0.001593186,0.000399849,0.003634033,0.0006802801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001018304,"about_ca_system_score_gemma":0.0007442966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000692887,"about_ca_topic_score_gemma":0.001285131,"domain_scores_codex":[0.9987265,0.0007917355,0.00005169005,0.0001719054,0.0001047319,0.000153405],"domain_scores_gemma":[0.99809,0.0007109274,0.000364399,0.0002182167,0.0001021198,0.000514339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9628132,0.003069651,0.002119022,0.0005209397,0.002374612,0.0001280905,0.00007480133,0.001086332,0.001817027,0.0001738742,0.001313896,0.02450868],"study_design_scores_gemma":[0.8871802,0.09571004,0.01032856,0.00007455588,0.00213748,0.0002401667,0.00004832861,0.001128241,0.0009340238,0.0006271311,0.001549097,0.00004217966],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909917,0.004755167,0.0003360797,0.0006962419,0.0002105538,0.0003974893,0.000664455,0.00006692855,0.001881446],"genre_scores_gemma":[0.9962897,0.0009344175,0.0002802244,0.0004392923,0.0002346141,0.0002324691,0.0004700722,0.00001364759,0.001105644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004776008,"threshold_uncertainty_score":0.01597732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1222978448838388,"score_gpt":0.3952200405295618,"score_spread":0.272922195645723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}