{"id":"W2160140858","doi":"10.6000/1927-7229.2014.03.01.1","title":"The Role of Secreted Frizzled Related Protein 4 (sFRP-4) in Regulating Oestradiol-Induced Growth of the MCF-7 Breast Cancer Cell Line","year":2014,"lang":"en","type":"article","venue":"Journal of Analytical Oncology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Frizzled; Wnt signaling pathway; LRP6; MCF-7; LRP5; Cancer research; Cell growth; Cell biology; Biology; Signal transduction; Hedgehog signaling pathway; Breast cancer; Cancer; Endocrinology; Genetics; Human breast","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009954441,0.0001285594,0.0003767688,0.00004302008,0.00005478022,0.000006451089,0.0003957688,0.0002562212,0.00003886048],"category_scores_gemma":[0.0002546332,0.00007439833,0.0001863655,0.0002146648,0.0001748931,0.000006537005,0.00008238911,0.0003107079,3.850437e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008816022,"about_ca_system_score_gemma":0.0004653402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001004964,"about_ca_topic_score_gemma":0.0001051165,"domain_scores_codex":[0.9982512,0.0002882176,0.0008630175,0.000145396,0.0002296608,0.0002224887],"domain_scores_gemma":[0.9984474,0.000103638,0.0008200326,0.000182582,0.0003773374,0.00006898061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005241254,0.0001112696,0.01243514,0.00002021227,0.0001559524,0.000002118911,0.00009075204,0.0002460411,0.9826659,0.0005096831,0.0001437409,0.003095054],"study_design_scores_gemma":[0.002395565,0.001334021,0.03975854,0.0001929576,0.0001454186,0.0000810186,0.0002409419,0.00420183,0.9481454,0.001648556,0.001655733,0.0002000562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966449,0.0005050192,0.0000472482,0.001169295,0.0001416777,0.0001271797,0.000003314978,0.000001592978,0.001359797],"genre_scores_gemma":[0.9991779,0.0001028875,0.0002185031,0.00005573725,0.0001879689,0.000004645854,0.000001845473,0.0000135101,0.0002369949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03452054,"threshold_uncertainty_score":0.3033876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00657797235904677,"score_gpt":0.2479339615327788,"score_spread":0.241355989173732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}