{"id":"W2160191948","doi":"10.1084/jem.20140131","title":"Niche displacement of human leukemic stem cells uniquely allows their competitive replacement with healthy HSPCs","year":2014,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McMaster University","funders":"","keywords":"Progenitor cell; Haematopoiesis; Stem cell; Leukemia; Biology; Immunology; Bone marrow; Niche; Myeloid leukemia; Transplantation; Cancer research; Cell biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001649683,0.0002480499,0.0007326361,0.0001308083,0.00009389234,0.000003788686,0.0002155417,0.00005616375,0.0002168199],"category_scores_gemma":[0.000009570208,0.000124335,0.00008151529,0.0001455283,0.0003563822,0.0000575641,0.00002737228,0.0003142054,0.000004015584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002684269,"about_ca_system_score_gemma":0.0001201084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005851323,"about_ca_topic_score_gemma":0.000007300408,"domain_scores_codex":[0.9974554,0.0003454422,0.0009998631,0.0001541651,0.0007997472,0.0002454379],"domain_scores_gemma":[0.9980185,0.0003614795,0.000824664,0.0003707717,0.0001992577,0.0002253035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005610359,0.0004176789,0.001436284,0.0002433309,0.0002550369,0.00001942074,0.01437397,0.00001782918,0.9755597,0.00119141,0.000724839,0.0001502107],"study_design_scores_gemma":[0.01041558,0.02318377,0.001028119,0.002510592,0.0003509494,0.0007481717,0.03131938,0.0000884396,0.9294683,0.00002306971,0.0007322604,0.0001314038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990374,0.001464767,0.001474427,0.001589896,0.0002237127,0.0006792846,0.000003464145,0.00001303848,0.004177467],"genre_scores_gemma":[0.9980367,0.0002613182,0.0003338783,0.0008961409,0.0001599005,0.000008320633,0.000007516374,0.00003221917,0.0002639974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04609136,"threshold_uncertainty_score":0.5070235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02638276961345438,"score_gpt":0.3045304162704613,"score_spread":0.278147646657007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}