{"id":"W2160191948","doi":"10.1084/jem.20140131","title":"Niche displacement of human leukemic stem cells uniquely allows their competitive replacement with healthy HSPCs","year":2014,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McMaster University","funders":"","keywords":"Progenitor cell; Haematopoiesis; Stem cell; Leukemia; Biology; Immunology; Bone marrow; Niche; Myeloid leukemia; Transplantation; Cancer research; Cell biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001301051,0.0002015459,0.0002357392,0.0001310319,0.00010839,0.0003511715,0.0001578955,0.0001200157,0.0008776326],"category_scores_gemma":[0.0001053572,0.00008283139,0.0001264482,0.000100682,0.0001726624,0.0001205848,0.0003319495,0.0003245621,0.0002859105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001500795,"about_ca_system_score_gemma":0.0001760639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004179713,"about_ca_topic_score_gemma":0.0006270517,"domain_scores_codex":[0.9998477,0.00002563544,0.000009690839,0.00003342101,0.00004869982,0.00003486067],"domain_scores_gemma":[0.9999336,0.00001524441,0.00001617118,0.00001260711,0.000004829019,0.00001749279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007022163,0.00001919809,0.0002565685,0.00001941173,0.000002304146,0.00003227573,0.00002511741,0.0001152572,0.9970967,0.0002083106,0.00003303007,0.002121615],"study_design_scores_gemma":[0.00001291109,0.0004638266,0.003084895,0.000005444445,0.0000133482,0.0003424971,0.00003803339,0.001293214,0.9902289,0.00006537251,0.0044483,0.000003348425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923679,0.001005499,0.005244298,0.00004118567,0.000009829108,0.00002892535,0.0001194224,0.00009994226,0.00108308],"genre_scores_gemma":[0.9963084,0.0003816061,0.002265085,0.00002663315,0.000006815514,0.00002225041,0.0001966786,0.00001567995,0.0007768474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008776326,"threshold_uncertainty_score":0.002935946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02638276961345438,"score_gpt":0.3045304162704613,"score_spread":0.278147646657007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}