{"id":"W2160216944","doi":"10.1093/annonc/mdv215","title":"Identifying clinically relevant prognostic subgroups of postmenopausal women with node-positive hormone receptor-positive early-stage breast cancer treated with endocrine therapy: a combined analysis of ABCSG-8 and ATAC using the PAM50 risk of recurrence score and intrinsic subtype","year":2015,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute for Health and Care Research; Cancer Research UK","keywords":"Medicine; Internal medicine; Breast cancer; Oncology; Anastrozole; Tamoxifen; Confidence interval; Stage (stratigraphy); Adjuvant therapy; Multivariate analysis; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003651631,0.0002206993,0.0007702544,0.0001172778,0.0000542316,0.000006219031,0.0001201987,0.00009059915,0.000003205869],"category_scores_gemma":[0.00007761814,0.0001397634,0.0000501648,0.0004563186,0.0009024451,0.00001593901,0.0001280388,0.000108351,4.964341e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003442616,"about_ca_system_score_gemma":0.0002404397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002515108,"about_ca_topic_score_gemma":0.0004322559,"domain_scores_codex":[0.9984477,0.000293929,0.0004646701,0.0003662584,0.0001796374,0.0002478682],"domain_scores_gemma":[0.9975241,0.000212528,0.0009316028,0.0002559478,0.0009891693,0.00008667043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02432756,0.0004981376,0.9267157,0.00003584643,0.006863812,0.000009876897,0.002054523,0.00006004312,0.03323855,0.00001278484,0.000008777679,0.006174387],"study_design_scores_gemma":[0.003343592,0.01500667,0.9524115,0.000115777,0.001152153,0.0000210864,0.0008723148,0.00002912725,0.02687974,0.00001342774,0.000006167395,0.0001484962],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954153,0.002929074,0.00005526994,0.0002041613,0.00001528128,0.0004140606,0.0009421387,0.000003646955,0.00002103277],"genre_scores_gemma":[0.9927342,0.006708254,0.0003642855,0.00004356601,0.00001785519,0.00004176503,0.0000678736,0.00001732283,0.000004858351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02569575,"threshold_uncertainty_score":0.5699387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04354790960364367,"score_gpt":0.3334416530865995,"score_spread":0.2898937434829558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}