{"id":"W2160220601","doi":"10.1534/genetics.114.173609","title":"The Dnmt1 Intrinsically Disordered Domain Regulates Genomic Methylation During Development","year":2014,"lang":"en","type":"article","venue":"Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institutes of Health; Génome Québec; McGill University","keywords":"Methylation; DNA methylation; Genomic imprinting; Biology; DNMT1; Methyltransferase; Epigenetics; RNA-Directed DNA Methylation; Genetics; DNA methyltransferase; Mutant; Molecular biology; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008202861,0.0001601558,0.00009864197,0.0001764976,0.0001144226,0.0002045717,0.000141213,0.0001204569,0.0005487946],"category_scores_gemma":[0.0001191135,0.0001256264,0.0001035525,0.00006885552,0.0001647709,0.0001383907,0.0002394628,0.0002455584,0.0002109158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002924527,"about_ca_system_score_gemma":0.0001431786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005235862,"about_ca_topic_score_gemma":0.001046394,"domain_scores_codex":[0.9999391,0.000006922884,0.000004446757,0.00002043348,0.00001598859,0.00001319954],"domain_scores_gemma":[0.9999186,0.00001195358,0.00002955589,0.00001014249,0.000009019835,0.00002075293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004101728,0.000001783862,0.00107291,0.000006997042,0.000001685231,0.00002614829,0.00001474521,0.00005342122,0.9971315,0.0000920829,0.000008233098,0.001549518],"study_design_scores_gemma":[0.000005810179,0.00007189679,0.03069111,0.000004460388,0.00001261797,0.0002921748,0.00002147434,0.0009478727,0.9662334,0.000123956,0.001590073,0.000005221534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946202,0.0007596919,0.003407692,0.00002669697,0.000004843978,0.000005093413,0.0002411057,0.00007268556,0.0008619597],"genre_scores_gemma":[0.9971098,0.0002730319,0.001341938,0.000009538603,0.000001713336,0.000004673811,0.0002172067,0.00001409366,0.001028098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005487946,"threshold_uncertainty_score":0.002121866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005242104510814197,"score_gpt":0.2150277142291223,"score_spread":0.2097856097183081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}