{"id":"W2160220601","doi":"10.1534/genetics.114.173609","title":"The Dnmt1 Intrinsically Disordered Domain Regulates Genomic Methylation During Development","year":2014,"lang":"en","type":"article","venue":"Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institutes of Health; Génome Québec; McGill University","keywords":"Methylation; DNA methylation; Genomic imprinting; Biology; DNMT1; Methyltransferase; Epigenetics; RNA-Directed DNA Methylation; Genetics; DNA methyltransferase; Mutant; Molecular biology; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004054386,0.000157411,0.0001051662,0.00003098131,0.000365735,0.00006338494,0.000221675,0.0001278014,0.000004777811],"category_scores_gemma":[0.00008709921,0.0001282052,0.00005526891,0.00007391848,0.00007108961,0.000001690722,0.0001615068,0.00007050086,0.00001862617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002260463,"about_ca_system_score_gemma":0.00005529908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001782188,"about_ca_topic_score_gemma":0.000104715,"domain_scores_codex":[0.9988327,0.0001154573,0.0003097777,0.0002994947,0.0001617468,0.0002808193],"domain_scores_gemma":[0.9992635,0.00003331237,0.0001126834,0.0004266957,0.00008724152,0.00007659118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003014202,0.0000173255,0.003239161,0.000008173541,0.00003353798,1.71137e-7,0.0001098153,0.001015693,0.9582008,0.0001814116,0.00003736268,0.03712642],"study_design_scores_gemma":[0.0003978292,0.00008377847,0.09018241,0.000004138943,0.000009199548,0.000001165378,0.0000341081,0.0002062811,0.7540126,0.002060118,0.1528056,0.0002027755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832895,0.002385963,0.01330075,0.0001893058,0.0001555755,0.0001808984,0.000001610609,0.00001482337,0.0004815309],"genre_scores_gemma":[0.9883828,0.0006783216,0.01010159,0.00003232253,0.0002861751,0.00002135878,0.00006073896,0.0000308382,0.0004058523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2041882,"threshold_uncertainty_score":0.5228055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005242104510814197,"score_gpt":0.2150277142291223,"score_spread":0.2097856097183081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}