{"id":"W2160222676","doi":"10.1042/bj20110571","title":"Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration","year":2011,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; University of Ottawa","keywords":"UCP3; Uncoupling protein; Oxidative phosphorylation; Reactive oxygen species; Mitochondrion; Biology; Hexokinase; Carbohydrate metabolism; Biochemistry; Oxidative stress; Cellular respiration; Metabolism; Mitochondrial ROS; Glycolysis; Cell biology; Adipose tissue; Brown adipose tissue","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001641467,0.0001628653,0.0002538042,0.00008544026,0.000186845,0.00002547912,0.00008072684,0.0001362792,0.000135209],"category_scores_gemma":[0.0005926244,0.0001322599,0.00006953574,0.000137898,0.0001126265,0.0002319957,0.00007497243,0.0003403673,0.00002212143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007399213,"about_ca_system_score_gemma":0.00007655728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001319974,"about_ca_topic_score_gemma":0.000002718351,"domain_scores_codex":[0.9988213,0.00005341966,0.000286811,0.0002915075,0.0002699651,0.0002769677],"domain_scores_gemma":[0.9991772,0.00001430734,0.0001137214,0.0002051623,0.0001794554,0.0003101781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001298882,0.0001607181,0.00005371289,0.00001340158,0.00005842638,0.00006249609,0.002538169,1.17776e-7,0.9727761,0.0006751316,0.02187538,0.0004874618],"study_design_scores_gemma":[0.0008943633,0.0004901837,0.004210853,0.0001253042,0.000153505,0.001053757,0.0004295452,6.197472e-7,0.9259635,0.0009745999,0.06554523,0.0001585272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943264,0.0005650506,0.00049102,0.002321332,0.0007720201,0.0003782407,0.000005104348,0.00002937295,0.001111484],"genre_scores_gemma":[0.9806153,0.0001250774,0.01309099,0.0005421801,0.004118369,0.00001212937,0.00001982756,0.00002473813,0.001451416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0468126,"threshold_uncertainty_score":0.5393403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04679199315533319,"score_gpt":0.2796643720595409,"score_spread":0.2328723789042077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}