{"id":"W2160268283","doi":"10.1074/jbc.m406289200","title":"Both the Sequence and Length of the C Terminus of PEN-2 Are Critical for Intermolecular Interactions and Function of Presenilin Complexes","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network; University of Toronto","funders":"","keywords":"Presenilin; Nicastrin; C-terminus; Transmembrane domain; Peptide sequence; Transmembrane protein; Cleavage (geology); Amyloid precursor protein; Function (biology); Biology; Biochemistry; Amino acid; Chemistry; Cell biology; Alzheimer's disease; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001465688,0.0004546545,0.0002482033,0.0001448481,0.0001977059,0.0004016596,0.0002471645,0.0003031118,0.00142718],"category_scores_gemma":[0.0002484555,0.0001732695,0.0002660171,0.0001131873,0.0002006019,0.0003001839,0.0002223248,0.0005052901,0.00049011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002970149,"about_ca_system_score_gemma":0.0003393526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005004148,"about_ca_topic_score_gemma":0.0006570052,"domain_scores_codex":[0.9998434,0.00002893466,0.00002175663,0.00003319223,0.00004041138,0.00003224077],"domain_scores_gemma":[0.9997211,0.0000526107,0.0001035264,0.0000233577,0.000026912,0.00007237912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008534952,0.00001956147,0.0003507345,0.00002976255,0.00000682568,0.0001148241,0.000008240396,0.0001258999,0.9984646,0.0000523544,0.00001295073,0.0007289566],"study_design_scores_gemma":[0.00002531813,0.0001426047,0.01538617,0.00001340829,0.00002906622,0.0009713758,0.0000406812,0.001073274,0.9806448,0.00009094519,0.001568656,0.000013533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997031,0.0006729467,0.001599867,0.0000427816,0.00001128246,0.00001308079,0.0001296067,0.00001620323,0.0004833247],"genre_scores_gemma":[0.9959848,0.0003333963,0.002409626,0.00005124367,0.000006679009,0.0000155889,0.0003820687,0.00001158232,0.0008050778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00142718,"threshold_uncertainty_score":0.004774392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06844346602390523,"score_gpt":0.3604326337603314,"score_spread":0.2919891677364261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}