{"id":"W2160272913","doi":"10.1128/aac.00564-11","title":"Coresistance to Isoniazid and Ethionamide Maps to Mycothiol Biosynthetic Genes in Mycobacterium bovis","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Ethionamide; Isoniazid; Biology; Mycobacterium smegmatis; Mycobacterium bovis; Mycobacterium tuberculosis; Mutant; DNA ligase; Microbiology; Gene; Genetics; Tuberculosis; Antibiotics; Medicine; Streptomycin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007271906,0.0001746974,0.0002088873,0.0004371283,0.0002426505,0.0004197477,0.0001667631,0.0002959924,0.0006269779],"category_scores_gemma":[0.000277663,0.0002371405,0.0001721495,0.000232931,0.0001803163,0.0001369859,0.0002366533,0.0002743757,0.0004154932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003154014,"about_ca_system_score_gemma":0.0001973852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002355491,"about_ca_topic_score_gemma":0.001840426,"domain_scores_codex":[0.9999176,0.000008431313,0.000008049406,0.00001747674,0.00002929416,0.00001906924],"domain_scores_gemma":[0.9997988,0.00004266055,0.00006487864,0.00002183312,0.00003956957,0.00003228228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008413535,0.00001681433,0.001555669,0.00001765,0.00000264203,0.0001310661,0.0000431502,0.00003662452,0.9959416,0.00006173033,0.00001286,0.002096005],"study_design_scores_gemma":[0.00004855542,0.0003906268,0.1704666,0.00003625455,0.00004571201,0.003951735,0.0003992913,0.001794868,0.8189811,0.0004751994,0.003391186,0.00001897335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998114,0.0003389387,0.0006486046,0.00004307441,0.000005252589,0.000007912928,0.00009445428,0.00001569603,0.0007320981],"genre_scores_gemma":[0.9976745,0.0001340869,0.0007567634,0.00002585218,0.000004571392,0.000006701643,0.0003118751,0.00001219872,0.001073486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002355491,"threshold_uncertainty_score":0.004683614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02827664793788499,"score_gpt":0.2769474729014879,"score_spread":0.2486708249636029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}