{"id":"W2160273104","doi":"10.1242/dmm.014126","title":"Denervation atrophy is independent from Akt and mTOR activation and is not rescued by myostatin inhibition","year":2014,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Myostatin; Denervation; Protein kinase B; Atrophy; Endocrinology; PI3K/AKT/mTOR pathway; Muscle atrophy; Internal medicine; Downregulation and upregulation; Biology; Muscle hypertrophy; Skeletal muscle; Phosphorylation; Cell biology; Medicine; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636807,0.000377634,0.0004810713,0.0002931785,0.0001465984,0.0002320879,0.0002390332,0.0002300617,0.001263944],"category_scores_gemma":[0.00009386147,0.0001463092,0.0003154989,0.0001384749,0.0003273583,0.0002555962,0.0002424489,0.0005946074,0.0002206057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002579174,"about_ca_system_score_gemma":0.000261139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006396134,"about_ca_topic_score_gemma":0.001723532,"domain_scores_codex":[0.9998112,0.00002338352,0.0000217013,0.0000420712,0.00005265751,0.00004892769],"domain_scores_gemma":[0.9998786,0.00001178894,0.00005163723,0.00001407018,0.00001220763,0.00003175921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003628808,0.00006276752,0.0005525894,0.0000642869,0.00001888185,0.0001117883,0.0000130902,0.00006476268,0.9970635,0.00007970308,0.0000297001,0.001576061],"study_design_scores_gemma":[0.00008555601,0.002542025,0.046535,0.00003252231,0.00007487293,0.001404353,0.0001006853,0.001227696,0.9457374,0.00009373684,0.002153831,0.00001238025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963876,0.002095914,0.0005180403,0.00004527615,0.00002326752,0.00001382586,0.0001243784,0.00003588052,0.0007557476],"genre_scores_gemma":[0.9954396,0.001396062,0.0005887923,0.00004665864,0.00001298836,0.00003218733,0.0004125588,0.00001426711,0.002057096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001263944,"threshold_uncertainty_score":0.004228294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008203835526766914,"score_gpt":0.2084119541849864,"score_spread":0.2002081186582195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}