{"id":"W2160273104","doi":"10.1242/dmm.014126","title":"Denervation atrophy is independent from Akt and mTOR activation and is not rescued by myostatin inhibition","year":2014,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Myostatin; Denervation; Protein kinase B; Atrophy; Endocrinology; PI3K/AKT/mTOR pathway; Muscle atrophy; Internal medicine; Downregulation and upregulation; Biology; Muscle hypertrophy; Skeletal muscle; Phosphorylation; Cell biology; Medicine; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007332775,0.0001479872,0.0001068311,0.000027698,0.0001163149,0.00002774109,0.00004612601,0.000136623,0.00002415594],"category_scores_gemma":[0.00002366746,0.0001519146,0.00003762553,0.00002808989,0.0000367864,0.00002244731,0.00006776545,0.00005574839,0.000002538234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007453362,"about_ca_system_score_gemma":0.00002217384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001016533,"about_ca_topic_score_gemma":0.00000680837,"domain_scores_codex":[0.9990821,0.00007020609,0.0001358656,0.0004373171,0.0001321203,0.0001424184],"domain_scores_gemma":[0.9995357,0.00001121794,0.00007397221,0.0001991894,0.00004781902,0.0001321066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005153122,0.0000632754,0.00006685777,0.00001734922,0.00002587566,2.732092e-7,0.0001366632,0.0000873476,0.9929973,0.002451813,0.001106346,0.002531571],"study_design_scores_gemma":[0.001512254,0.0002640553,0.002669363,0.00002324715,0.00005697026,2.647494e-7,0.00008662377,0.02320499,0.8246881,0.146786,0.0003872294,0.0003209048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8108836,0.0001366645,0.1880708,0.0005245515,0.00002985833,0.0001401868,0.0001740657,0.00001172053,0.00002858088],"genre_scores_gemma":[0.9936414,0.0001149039,0.0006580402,0.004282345,0.00005781587,0.00004090443,0.001137973,0.00001834903,0.0000483168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1874128,"threshold_uncertainty_score":0.6194899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008203835526766914,"score_gpt":0.2084119541849864,"score_spread":0.2002081186582195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}